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GMCL1 Controls 53BP1 Stability and Modulates Paclitaxel Sensitivity in Cancer
23 May 2025 20:41 GMT
… paclitaxel, cabazitaxel, and/or docetaxel (Figure 3A-C). In contrast, lung cancer … nearly half of lung cancers harbor p53 mutations30, … levels and restores paclitaxel sensitivity.
These observations … GMCL1 BTB.
Taxol resistance analysis
Taxol resistance was …
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Verastem Oncology announces positive results from RAMP 205 evaluating avutometinib plus defactinib in combo with standard─of─care chemotherapy in frontline metastatic PDAC
24 May 2025 13:22 GMT
… with gemcitabine and Nab-paclitaxel in the front-line … defactinib with gemcitabine and Nab-paclitaxel in frontline metastatic PDAC. … #47;m2 of Nab-paclitaxel on a schedule of day … G12C mutant non-small cell lung cancer (RAMP 203; NCT05074810). Avutometinib …
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ASCO 2025: The Presentations That May Shift the Cancer Care Paradigm
23 May 2025 18:30 GMT
… with gemcitabine/nab-paclitaxel (GnP) versus GnP alone … plus gemcitabine/nab-paclitaxel (GnP) vs GnP alone … which include non–small cell lung cancer (NSCLC) and melanoma.8 … treated metastatic non-small cell lung cancer (NSCLC) or cutaneous melanoma …
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ASCENT-03: Trodelvy® Demonstrates Highly Statistically Significant & Clinically Meaningful Improvement in Progression Free Survival in Patients With First-line Metastatic Triple-Negative Breast Cancer Who Are Not Candidates for Checkpoint Inhibitors
23 May 2025 12:41 GMT
… included gemcitabine plus carboplatin, paclitaxel, or nab-paclitaxel. Treatment continued until blinded … than 90% of breast and lung cancers. Trodelvy is intentionally designed with …
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RWJBarnabas Health and Rutgers Cancer Institute to Present Practice-Changing Research at 2025 ASCO Annual Meeting
23 May 2025 02:57 GMT
… combination with nab-paclitaxel versus nab-paclitaxel monotherapy in … of pembrolizumab, carboplatin, paclitaxel, and radiation for the … on gemcitabine/nab-paclitaxel (GN) and GN… oligometastatic non small cell lung cancer treated with combination …
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HUTCHMED Highlights Clinical Data to be Presented at the 2025 ASCO Annual Meeting
23 May 2025 00:00 GMT
… -positive non-small cell lung cancer (“NSCLC”) with MET … LBA8505
Oral Abstract Session: Lung Cancer - Non-Small Cell … 8513
Rapid Oral Session: Lung Cancer - Non-Small Cell … of fruquintinib plus paclitaxel versus paclitaxel in gastroesophageal junction …
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Daiichi Sankyo Continues to Transform Treatment Landscape for Patients with Cancer with Practice-Changing Data at ASCO
22 May 2025 21:03 GMT
… compared to ramucirumab and paclitaxel as a second-line … -progress poster presentations in lung cancer across the DXd ADC … or metastatic non-small cell lung cancer: results from TROPION-Lung04 … and non-small cell lung cancers, and leptomeningeal disease from …
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Verastem Oncology Announces Positive Updated Results from RAMP 205 Evaluating Avutometinib Plus Defactinib in Combination with Standard-of-Care Chemotherapy in Frontline Metastatic Pancreatic Ductal Adenocarcinoma
22 May 2025 21:29 GMT
… with gemcitabine and Nab-paclitaxel in the front-line … defactinib with gemcitabine and Nab-paclitaxel in frontline metastatic PDAC. … #47;m2 of Nab-paclitaxel on a schedule of day … G12C mutant non-small cell lung cancer (RAMP 203; NCT05074810). Avutometinib …
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Guardant Health and Collaborators to Present Over 19 Studies Demonstrating Role of Liquid Biopsy in Advancing Precision Oncology at 2025 ASCO Annual Meeting
22 May 2025 21:29 GMT
… and non-small cell lung cancer samples, utilizing genomic and … metastatic non-small cell lung cancer (mNSCLC)
Guardant360 Liquid
… Durvalumab plus carboplatin/paclitaxel followed by durvalumab with … in non-small cell lung cancer
Guardant360 Liquid
e13084
…
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Brain Delivery Strategies for Biomacromolecular Drugs: Intranasal Administration
22 May 2025 15:04 GMT
… HER2-mutant non-small-cell lung cancer. N Engl J Med. 2022 … ALK-mutated non-small-cell lung cancer (ATTLAS, KCSG-LU19-04). J … -brain delivery of cancer-targeting paclitaxel-loaded nanoparticles potentiates antitumor effects …
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