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<![CDATA[Ibtrozi Emerging as New Standard for ROS1-Mutated Lung Cancer]]>
26 Sep 2025 21:30 GMT
… phase 2 TRUST-II clinical trial evaluating Ibtrozi (taletrectinib) in patients … with existing options such as Xalkori (crizotinib), Mekinist (trametinib) and Augtyro … points in their treatment journey — either as the first drug given or …
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<![CDATA[ROS1-Directed Therapies Lead the Way in NSCLC]]>
25 Sep 2025 19:03 GMT
… Xalkori), oncologists can now choose from an array of later-generation drugs … professor of clinical medicine at the Keck … trials [that are similar to] the [phase 3] FLAURA2 trial … Population-adjusted indirect treatment comparisons of repotrectinib among …
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Immunotherapy and T-Cell–Directed Therapy Expand Treatment Approaches in Small Cell Lung Cancer
14 Aug 2025 18:48 GMT
… as the Clinical Research Medical Director at the … personalized treatments, novel targets, and innovative approaches. Antibody-drug … 3 CROWN (NCT03052608) trials advanced the understanding of … inhibitor, with crizotinib [Xalkori], an earlier-generation ALK …
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Array of Agents Allow for Treatment Individualization in ROS1+ NSCLC
27 Jul 2025 14:46 GMT
… of crizotinib (Xalkori), later generations of drugs in the realm … associate professor of clinical medicine at the University of Southern … the other agents. Treatment with the drug does not lead to … more trials [that are similar to] the [phase 3] FLAURA2 trial …
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Trump to sign executive order to reduce cost of prescription drugs and pharmaceuticals up to 80%
12 May 2025 02:18 GMT
… wrote.
'The Pharmaceutical/Drug Companies would say, … Xeljanz, a treatment for autoimmune diseases including … Xalkori.
Drugmakers hiked up the prices of more than 770 drugs in 2024 alone — including medications … seen by a doctor. With insurance, copays …
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Pledging ‘Radical Transparency,’ FDA Reveals Drug Rejection Letters — With Limits
13 Jul 2025 18:50 GMT
… established ROS1 inhibitors Xalkori from Pfizer and … vaccine as mNEXSPIKE. In the key clinical trial … FDA approved KalVista Pharmaceuticals’ Ekterly, making the pill the first oral on-demand treatment … a drug that the biotech had developed as a treatment for …
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FDA Backs Darovasertib Phase 3 Trial Design in Uveal Melanoma
14 Apr 2025 23:38 GMT
… trial," said Darrin Beaupre, MD, PhD, chief medical … its combination with crizotinib (Xalkori) in metastatic uveal … IDEAYA Biosciences receives US FDA breakthrough therapy designation … drug designation for darovasertib, a PKC inhibitor, for the treatment …
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Navigating the Treatment Landscape in Non–Clear Cell Renal Cell Carcinoma
23 Jun 2025 14:42 GMT
… features, biologies, and treatment responses. nccRCC histologies … from RCC clinical trials, which mainly enrolled … investigator-initiated randomized trial, patients with untreated … inhibitors cabozantinib, crizotinib (Xalkori), or savolitinib (Orpathys …
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Chasing rivals, Nuvalent to seek approval of targeted lung cancer drug
24 Jun 2025 17:19 GMT
… similar medicines, according to results from a clinical trial … expansion” for the drug. A similar medicine from Nuvation Bio … drugs are available for these cancers, among them Pfizer’s Xalkori … sluggish uptake of existing treatments reflects issues like …
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Real-World Lung Cancer Data Links Biomarker Status to Survival and Medication Costs
19 Jun 2025 21:02 GMT
… stage. Newer treatments like targeted therapies (such as Tagrisso, Xalkori, and others … estimates were based primarily on Medicare reimbursement rates and supplemented with … develop cheaper or more effective medications for these patients,” the authors …