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UK invests £60m to phase out animal testing in preclinical trials
12 Nov 2025 21:59 GMT
… Association of the British Pharmaceutical Industry’s (ABPI) … to develop new medicines and vaccines. While the science … in drug evaluation” that could accelerate access to treatments while … testing MSD’s FDA-approved therapy Zolinza (vorinostat). AstraZeneca, …
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<![CDATA[FDA Grants Tinostamustine Orphan Drug Designation for Malignant Gliomas]]>
12 Nov 2025 21:37 GMT
… FDA orphan drug designation (ODD) for first-line treatment of … promise in early trials."
Tinostamustine is … fusing the chemotherapy medications bendamustine and vorinostat. Through this … . National Center for Biotechnology Information. PubChem Compound …
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Pembrolizumab/Vorinostat Has Promising Activity in Squamous Cell Carcinoma
10 Jul 2025 23:44 GMT
… . Additionally, the study treatment produced a median progression … combination of pembrolizumab and vorinostat showed promising antitumor activity … , from the Department of Drug Development and Innovation (D3i … dose of study treatment.
The trial’s primary end …
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A Minireview on Nanosized Hypericin-Based Inducer of Immune Cell Death Under ROS-Based Therapies
08 Dec 2025 22:04 GMT
… drugs, can convert malignant cells into potent vaccines, … antimicrobial, anti-inflammatory, antidepressant, and anticancer effects.26 … valproic acid and vorinostat enhance trastuzumab-mediated … of nanotechnology in cancer treatment. Pharmaceutics. 2023;15(6): …
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Thumbay International Research Grant awards 14 projects at Gulf Medical University
18 Apr 2025 00:06 GMT
… initiative, stating, “We launched this grant to transform Gulf Medical University into … Using Machine Learning
Drug Discovery/Precision Medicine
RAK Medical and Health Sciences … in TNBC
Precision Medicine
Ajman University, UAE – Role of Vorinostat in Skin …
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Application of Multifunctional Metal Nanoparticles in the Treatment of Glioma
15 Jan 2025 20:04 GMT
… medical imaging and cancer treatment. The excellent biocompatibility and drug … of Minocycline and Vorinostat Targets the Tumor Microenvironment … Based on Nano-Biotechnology in the Treatment of Glioma. … Gold Nanoparticles. Mol Pharmaceut. 2019;16:2430–2444 …
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Prescient Therapeutics welcomes US FDA allowance of...
23 Dec 2024 00:16 GMT
… potential to address key unmet medical needs in T-cell lymphomas … -100 has Orphan Drug Designation from the US FDA for all T … associated with standard care treatment vorinostat.
The Phase 1b trial remains open, with …
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Discovery of a Novel and Potent Dual-Targeting Inhibitor of ATM and HDAC2 Through Structure-Based Virtual Screening for the Treatment of Testicular Cancer
19 Nov 2024 13:24 GMT
… in clinical cancer treatment, including vorinostat, romidepsin, and … Committee of China Pharmaceutical University (permit number … trials.16 In clinical practice, the HDAC inhibitor vorinostat … developing anti-cancer drugs. Comput. Struct. Biotechnol. J. …
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Molecular Insights into Phytochemicals Mediated Epigenetic Regulation in Preclinical Models of Breast Cancer
27 Nov 2025 10:27 GMT
… used as chemotherapeutic drugs for cancer treatment.149,150 … limit their potential as medicinal drug or formulation. Many … challenges, and future perspectives. Pharmaceuticals. 2025;18(2):207. … its combination with Vorinostat induces apoptotic-mediated cell …
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The Advances in the Development of Epigenetic Modifications Therapeutic Drugs Delivery Systems
18 Oct 2024 12:49 GMT
… profiles of these medications, ultimately leading to improved treatment outcomes.
Figure … clinical trials were isohydroxamic acid analogs.69 The FDA-approved drug vorinostat first … trial data for nano-based epigenetic drugs in breast cancer treatment …