-
Targeted Degradation of Histone Deacetylase 8 Using Proteolysis Targeting Chimeras Technology: A Promising Approach for Glioblastoma Treatment
22 Jan 2026 16:54 GMT
… clinical trials for glioblastoma treatment. In recurrent glioblastoma, vorinostat monotherapy … University, the Chakri Naruebodindra Medical Institute, and the … I/II trial of vorinostat combined with temozolomide … prologue. Nat Rev Drug Discov. 2022;21( …
-
Simultaneous Determination of Venetoclax and Posaconazole in Human Plasma by UPLC-MS/MS: Application to Therapeutic Drug Monitoring in Acute Myeloid Leukemia Patients
12 Jan 2026 04:27 GMT
… medications, varied from those in Agarwal’s study, potentially influencing drug … , phase 3 trial of decitabine vs treatment choice of supportive … with acute myeloid leukemia. Pharmaceutics. 2023;15(6):1680. … Phase I study of vorinostat in patients with advanced …
-
UK invests £60m to phase out animal testing in preclinical trials
12 Nov 2025 21:59 GMT
… Association of the British Pharmaceutical Industry’s (ABPI) … to develop new medicines and vaccines. While the science … in drug evaluation” that could accelerate access to treatments while … testing MSD’s FDA-approved therapy Zolinza (vorinostat). AstraZeneca, …
-
<![CDATA[FDA Grants Tinostamustine Orphan Drug Designation for Malignant Gliomas]]>
12 Nov 2025 21:37 GMT
… FDA orphan drug designation (ODD) for first-line treatment of … promise in early trials."
Tinostamustine is … fusing the chemotherapy medications bendamustine and vorinostat. Through this … . National Center for Biotechnology Information. PubChem Compound …
-
World Clinical Trials Arena UK invests £60m to phase out animal testing in preclinical trials
12 Nov 2025 12:37 GMT
… Association of the British Pharmaceutical Industry’s (ABPI) … to develop new medicines and vaccines. While the science … in drug evaluation” that could accelerate access to treatments while … testing MSD’s FDA-approved therapy Zolinza (vorinostat). AstraZeneca, …
-
Pembrolizumab/Vorinostat Has Promising Activity in Squamous Cell Carcinoma
10 Jul 2025 23:44 GMT
… . Additionally, the study treatment produced a median progression … combination of pembrolizumab and vorinostat showed promising antitumor activity … , from the Department of Drug Development and Innovation (D3i … dose of study treatment.
The trial’s primary end …
-
Breakthrough AI uncovers promising Rett syndrome treatment
03 Jul 2025 02:37 GMT
… Medicine.
Because vorinostat has already been approved by the Food and Drug Administration (FDA … n-of-1 trial design" to evaluate different vorinostat treatments within individual patients … trofinetide to human clinical trials in the past," said …
-
AI Reveals Repurposed Drug as Promising New Rett Syndrome Candidate
03 Jul 2025 04:28 GMT
… the drug known as vorinostat—an HDAC inhibitor FDA-approved for the treatment of … published in Communications Medicine in the paper, “AI-enabled drug prediction and … “n-of-1 trial design” to evaluate different vorinostat treatments within individual patients …
-
Thumbay International Research Grant awards 14 projects at Gulf Medical University
18 Apr 2025 00:06 GMT
… initiative, stating, “We launched this grant to transform Gulf Medical University into … Using Machine Learning
Drug Discovery/Precision Medicine
RAK Medical and Health Sciences … in TNBC
Precision Medicine
Ajman University, UAE – Role of Vorinostat in Skin …
-
FDA to phase out animal testing with AI and lab-based models
11 Apr 2025 13:41 GMT
… previously studied drugs without repeating animal trials. While … drug evaluation” that could accelerate access to treatments … the scientific community. Medical sciences professional Paniz … MSD’s FDA-approved therapy Zolinza (vorinostat).
In parallel …