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Pembrolizumab/Vorinostat Has Promising Activity in Squamous Cell Carcinoma
10 Jul 2025 23:44 GMT
… . Additionally, the study treatment produced a median progression … combination of pembrolizumab and vorinostat showed promising antitumor activity … , from the Department of Drug Development and Innovation (D3i … dose of study treatment.
The trial’s primary end …
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Breakthrough AI uncovers promising Rett syndrome treatment
03 Jul 2025 02:37 GMT
… Medicine.
Because vorinostat has already been approved by the Food and Drug Administration (FDA … n-of-1 trial design" to evaluate different vorinostat treatments within individual patients … trofinetide to human clinical trials in the past," said …
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AI Reveals Repurposed Drug as Promising New Rett Syndrome Candidate
03 Jul 2025 04:28 GMT
… the drug known as vorinostat—an HDAC inhibitor FDA-approved for the treatment of … published in Communications Medicine in the paper, “AI-enabled drug prediction and … “n-of-1 trial design” to evaluate different vorinostat treatments within individual patients …
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Thumbay International Research Grant awards 14 projects at Gulf Medical University
18 Apr 2025 00:06 GMT
… initiative, stating, “We launched this grant to transform Gulf Medical University into … Using Machine Learning
Drug Discovery/Precision Medicine
RAK Medical and Health Sciences … in TNBC
Precision Medicine
Ajman University, UAE – Role of Vorinostat in Skin …
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FDA to phase out animal testing with AI and lab-based models
11 Apr 2025 13:41 GMT
… previously studied drugs without repeating animal trials. While … drug evaluation” that could accelerate access to treatments … the scientific community. Medical sciences professional Paniz … MSD’s FDA-approved therapy Zolinza (vorinostat).
In parallel …
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Application of Multifunctional Metal Nanoparticles in the Treatment of Glioma
15 Jan 2025 20:04 GMT
… medical imaging and cancer treatment. The excellent biocompatibility and drug … of Minocycline and Vorinostat Targets the Tumor Microenvironment … Based on Nano-Biotechnology in the Treatment of Glioma. … Gold Nanoparticles. Mol Pharmaceut. 2019;16:2430–2444 …
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Prescient Therapeutics welcomes US FDA allowance of...
23 Dec 2024 00:16 GMT
… potential to address key unmet medical needs in T-cell lymphomas … -100 has Orphan Drug Designation from the US FDA for all T … associated with standard care treatment vorinostat.
The Phase 1b trial remains open, with …
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Cutaneous T-cell Lymphoma Market Anticipates Impressive Growth Trajectory at a CAGR of 7.1% During the Study Period (2020–2034) | DelveInsight
21 Jul 2025 17:00 GMT
… -drug conjugates (e.g., mogamulizumab, brentuximab vedotin). Treatment … vorinostat). Notably, vorinostat was the first HDAC inhibitor to gain FDA … SymBio Pharmaceuticals, AVM Biotechnology, Autolus Therapeutics, Kymera Therapeutics, Otsuka Pharmaceutical, …
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Discovery of a Novel and Potent Dual-Targeting Inhibitor of ATM and HDAC2 Through Structure-Based Virtual Screening for the Treatment of Testicular Cancer
19 Nov 2024 13:24 GMT
… in clinical cancer treatment, including vorinostat, romidepsin, and … Committee of China Pharmaceutical University (permit number … trials.16 In clinical practice, the HDAC inhibitor vorinostat … developing anti-cancer drugs. Comput. Struct. Biotechnol. J. …
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The Advances in the Development of Epigenetic Modifications Therapeutic Drugs Delivery Systems
18 Oct 2024 12:49 GMT
… profiles of these medications, ultimately leading to improved treatment outcomes.
Figure … clinical trials were isohydroxamic acid analogs.69 The FDA-approved drug vorinostat first … trial data for nano-based epigenetic drugs in breast cancer treatment …