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Zanidatamab Plus Chemotherapy Shows Promising Anti-Tumor Activity in Treatment of HER2-Mutated Breast Cancer
21 May 2025 23:08 GMT
… (HER2)-mutated metastatic breast cancer (mBC). The data … for Medical Oncology Breast Cancer 2025 Annual Meeting … Genentech, Roche), lapatinib (24%; Tykerb; Novartis), trastuzumab deruxtecan (9% … HER2-mutated metastatic breast cancer, particularly those who …
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Durvalumab Plus Tremelimumab and Trastuzumab Yields Clinical Activity in Trastuzumab-Resistant HER2+ Breast Cancer
16 May 2025 22:44 GMT
… resistant advanced HER2-postive breast cancer,” lead study author … , incurable HER2-positive breast cancer, irrespective of PD- … 4%; 17%) and lapatinib (Tykerb; 20%; 12%; 6%). Most … breast cancer: BCT1703 DIAmOND. Presented at: 2025 ESMO Breast Cancer Congress …
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Zanidatamab/Chemotherapy Yields Responses and Is Safe in HER2-Expressing Metastatic Breast Cancer
16 May 2025 22:44 GMT
… patients with HER2-positive metastatic breast cancer who had previously received HER2 … advanced or metastatic HER2-expressing breast cancer with an ECOG performance status … ; 73%), pertuzumab (87%; 67%), lapatinib (Tykerb; 23%; 27%), tucatinib (6%; 13% …
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New ADCs Aim to Strengthen the HER2+ Breast Cancer Paradigm and Join T-DXd and T-DM1
06 May 2025 14:44 GMT
… with HER2-positive metastatic breast cancer and again when it … survival (PFS) vs lapatinib (Tykerb) plus capecitabine and showed … Congress on the Future of Breast Cancer® (IBC) occurring on … ;West...[for] HER2-positive breast cancer in the curative setting, …
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Pyrotinib-Based Therapy May Improve Survival in Patients With HER2+ Breast Cancer and Liver Metastases
25 Apr 2025 15:47 GMT
… (HER2+) advanced metastatic breast cancer (mBC) with liver … compared with the lapatinib (Tykerb; GSK)-capecitabine regimen. … positive liver metastatic advanced breast cancer. Front Oncol. April … for HER2-positive metastatic breast cancer: a systematic review …
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Study Links PAK5 to Poor Outcomes and Drug Resistance in HER2-Positive Breast Cancer
23 Apr 2025 17:13 GMT
… receptor-positive (HER2+) breast cancer (BC), according to … understand how PAK5 affects breast cancer, researchers measured its … both trastuzumab and lapatinib (Tykerb; GSK), another targeted … accumulation in HER2-positive breast cancer. Cell Death & …
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Neratinib Generates CNS Responses Across HER2+ Breast Cancer Brain Metastases Subgroups
10 Mar 2025 21:27 GMT
… treatments specifically targeting HER2-positive breast cancer brain metastases,” the authors explained … patients with no prior lapatinib (Tykerb) exposure, and cohort 3B ( … sequencing treatments for patients with breast cancer brain metastases,” the authors …
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Systemic Therapies Are Now Preferred in Some Patients With HER2+ Breast Cancer Brain Metastases
08 Mar 2025 19:13 GMT
… T-DM1, lapatinib (Tykerb) plus capecitabine, and … with HER2-positive metastatic breast cancer for brain metastases … HER2+ Breast Cancer. Presented at: 42nd Annual Miami Breast Cancer Conference. … HER2-positive metastatic breast cancer and brain metastases: …
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ARX788 Displays Activity in HER2+ Advanced Breast Cancer
05 Mar 2025 16:37 GMT
… ) benefit vs lapatinib (Tykerb) plus capecitabine for the … HER2-positive advanced breast cancer who experienced disease … or metastatic breast cancer or locally advanced breast cancer not amenable … HER2-positive advanced breast cancer. Signal Transduct Target …
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Tanshinlactone May Inhibit the Growth of ER+, HER2+, or EGFR-Mutated Cells in Breast Cancer
24 Feb 2025 19:58 GMT
… and EGFR-positive (EGFR+) breast cancer (BC). The data … cells. The anti-breast cancer effect happens when … tanshinlactone worked against breast cancer cells that resist (Tykerb; Novartis), a … Tanshinlactone triggers methuosis in breast cancer cells via NRF2 …