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<![CDATA[Updates in Treatment of Unresectable Hepatocellular Carcinoma ]]>
18 Dec 2025 03:03 GMT
… previously exposed to sorafenib. While both trials were conducted before … on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial. … Pharmaceuticals Inc; 2020. https://www.accessdata.fda.gov/drugsatfda_docs …
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Current Knowledge of the Integrated Stress Response in the Development and Management of Acute Myeloid Leukemia: A Novel Target with Encouraging Progress
16 Dec 2025 20:19 GMT
… drug approved by the FDA in 1999 for the treatment … synergistic antitumor activity with sorafenib in the MOLM14 AML … from the traditional herbal remedy dandelion, has been shown … Research of Zhejiang Chinese Medicine University for Affiliated Hospital …
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Liver Resection versus Targeted Therapy Plus PD-1 Inhibitors in Hepatocellular Carcinoma with Type I-II Portal Vein Tumor Thrombus: A Comparative Study
15 Dec 2025 17:34 GMT
… China; 5Graduate School, China Medical University, Shenyang, People’s … and other Phase 3 trials has made targeted therapy … the appropriate treatment based on the doctor’s recommendation … . Lenvatinib versus sorafenib in first-line treatment of patients with …
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Dihydroartemisinin: A Promising Therapeutic Agent Against the Hepatitis-to-Hepatocellular Carcinoma Cascade
15 Dec 2025 10:47 GMT
… compound isolated from the medicinal plant Artemisia annua. Extensive … migration.80
DHA Reduces Drug Resistance and Boosts … A Phase II clinical trial demonstrated that SRF plus … efficacy compared to sorafenib monotherapy. Treatment-related adverse events …
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Taurine-Modified Gossypol Exerts Dual Anti-Hepatocellular Carcinoma Effects by Inactivating PI3K/AKT Pathway and Targeting FASN-Mediated Lipid Metabolism in Regulatory T Cells
15 Dec 2025 10:47 GMT
… ” in traditional Chinese medicine theory, which is … Derived Organoid Culture and Drug Treatment
Fresh HCC tissues were … pharmacological mechanism of Xihuang pills in antitumor therapy. … , therapeutic hurdle confronting sorafenib and immune checkpoint inhibitors …
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Exploring the Therapeutic Potential of Ferroptosis in Gastric Cancer
19 Dec 2025 14:01 GMT
… design of future clinical trials and overcome clinical … as accessible complementary medicines for cancer treatment.42 Effects … 87 Sorafenib is approved by the Food and Drug Administration (FDA) … amplified ferroptosis. Front Bioeng Biotechnol. 2023;11:1171450. …
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The TBS-PALB-NLR Triad: A Novel Preoperative Prognostic System Guiding Therapeutic Decision-Making in Unresectable HCC Treated with Transarterial Chemoembolization
19 Dec 2025 14:01 GMT
… who underwent TACE treatment at three medical institutions in … liver disease background, and treatment response. Therefore, the … in future prospective clinical trials.
Conclusion
The TPN … patients undergoing TACE plus sorafenib: a Chinese multicenter …
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The Combined ALBI-FIB-4 Score for Prognostic Stratification in Hepatocellular Carcinoma: A Single Center Retrospective Study
18 Dec 2025 00:28 GMT
… retrieved from the institutional electronic medical records and reviewed retrospectively. … either as initial treatment or after local treatment failure), sorafenib was the most … enhance patient stratification for clinical trials, and help identify candidates …
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<![CDATA[FOG-001 Is Safe, Yields Antitumor Activity in Desmoid Tumors]]>
17 Dec 2025 22:41 GMT
… -001.
Data from the trial supported the FDA’s fast track designation … were either nirogacestat (Ogsiveo; 75%), sorafenib (Nexavar; 50%), cytotoxic chemotherapy (41 … , for the treatment of desmoid tumors. News release. Parabilis Medicines. November 12 …
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ER Stress Triggers Cell Death in Tumor Environment
17 Dec 2025 22:16 GMT
… against apoptosis, contributing to sorafenib resistance. Interventions that modulate … immune infiltration and attenuated treatment responses, illuminating the translational … collapse, thus overcoming conventional drug resistance mechanisms.
Therapeutic …