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In Situ Vaccination with Poly-ICLC Combined with Systemic Nivolumab for the Treatment of Unresectable Hepatocellular Carcinoma
14 Jun 2025 15:00 GMT
… the results achieved with sorafenib.6 Nevertheless, there remains … efficacy, and numerous trials are ongoing to explore … biological agents, or anti-cancer medications, (2) uncontrolled intercurrent … to the first dose of trial treatment, (5) active autoimmune …
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Rewrite The role and mechanism of fatty acid oxidation in cancer drug resistance as a headline for a science magazine post, using no more than 8 words
13 Jun 2025 12:18 GMT
… drugs, such as sorafenib, olaparib and bevacizumab, are a class of drugs … resistance of HCC cells to sorafenib [122]. Tumor-initiating … of HCC TIC to sorafenib [125]. Another study … US Food and Drug Administration (FDA) for the treatment of clinical …
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Preliminary Casdozokitug Activity in HCC Supports Further Exploration of IL-27 as a Treatment Target
09 Jun 2025 15:52 GMT
… early-phase clinical trials as a mechanism … the Department of Medical Oncology and Therapeutics …
All patients experienced treatment-emergent adverse effects … trial (NCT04723004), which evaluated first-line bevacizumab plus toripalimab vs sorafenib …
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Hepatocellular Carcinoma Market Gains Momentum as Immunotherapy and Targeted Treatments Redefine Care | CI Insights
04 Jun 2025 16:36 GMT
… as immunotherapies, targeted drugs, and novel … sorafenib in the landmark IMbrave150 trial, fundamentally shifting the treatment … advancing through clinical trials. Agents targeting the … -looking.
For pharmaceutical companies, biotech firms, and investors …
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Anlotinib/Penpulimab Enhances Survival vs Sorafenib in Unresectable HCC
30 May 2025 12:01 GMT
… parallel-controlled, phase 3 APOLLO trial (NCT04344158) published in Lancet Oncology … effect on treatment exposure.”
Investigators in the phase 3 trial randomly … #47;penpulimab and sorafenib groups, respectively, received local treatment for HCC, including …
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20 Studies Show the Cancer-Fighting Potential of this Low-Cost Drug
30 May 2025 16:23 GMT
… – Ivermectin synergizes sorafenib in hepatocellular carcinoma … Treatment?” was just published in the journal Acta Poloniae Pharmaceutica – Drug … large-scale clinical trials should be launched … doctor and compounded by a 50-state licensed pharmacy.
Medication …
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Carrier-Free Silibinin/Sorafenib Microparticles Alleviate Metabolic Dysfunction-Associated Steatotic Liver Disease by Modulating Fatty Acid Metabolism
29 May 2025 16:49 GMT
… clinical practice, the main medications used for MASLD include … being explored in clinical trials, they are still in … Sorafenib, a multi-targeted anticancer drug, is the first-line treatment … biological barriers to drug delivery. Nature Biotechnol. 2015;33(9 …
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Efficacy Data Support Nivolumab/Ipilimumab as First-Line HCC Treatment
23 May 2025 01:12 GMT
… compared with lenvatinib (Lenvima) or sorafenib (Nexavar) in patients with previously … at Kindai University Faculty of Medicine, as well as an executive … this trial, the FDA approved nivolumab plus ipilimumab in the first-line treatment …
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Brain Delivery Strategies for Biomacromolecular Drugs: Intranasal Administration
22 May 2025 15:04 GMT
… medications (ASMs) have been developed for epilepsy treatment.133 However, these drugs … with sorafenib: the checkmate 040 randomized clinical trial. JAMA … Cells Nanomed Biotechnol. 2018;46(8):2088 … Nose-to-Brain” drug delivery. Pharmaceutics. 2019;11(2):84 …
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Transarterial Chemoembolization, Molecular Targeted Treatments, and Programmed Death-(Ligand)1 Inhibitors, for Hepatocellular Carcinoma with Lung Metastasis: A Retrospective Cohort Study
22 May 2025 15:02 GMT
… targeted drugs.4 The TACTICS trial confirmed that TACE combined with sorafenib … Affiliated Hospital of Southwest Medical University and West China … Locoregional Treatment for Hepatocellular Carcinoma: possible Roles of Adjuvant Immunotherapy. Pharmaceutics. …