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Secretory leukocyte protease inhibitor influences periarticular joint inflammation in Borrelia burgdorferi-infected mice
20 May 2025 20:45 GMT
Lyme arthritis has been extensively documented and studied in patients and B. burgdorferi-infected mice. The pathogenesis of Lyme arthritis is characterized by synovial tissue damage caused by infiltration of immune cells and excessive pro-inflammatory …
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Design and Evaluation of Andrographolide Analogues as SARS-CoV-2 Main Protease Inhibitors: Molecular Modeling and in vitro Studies
15 May 2025 08:29 GMT
… bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced … oral SARS-CoV-2 3CL protease inhibitor clinical candidate for treating COVID … identifies SARS-CoV-2 main protease inhibitors with broad-spectrum activity against …
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HIV, AIDS, and Protease Inhibitors
04 May 2025 01:08 GMT
… a protease inhibitor in com bination with two other AIDS drugs. Protease inhibitors … combination therapies.”
By themselves protease inhibitors were ineffective, but when … from protease inhibitors.
While there is no doubt that protease inhibitors have …
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HIV: As Scientists Inch Closer to a Vaccine, Cuts to Funding Could Stall Progress
14 Jun 2025 15:49 GMT
… into human DNA inside cells.
Protease inhibitors (PIs) such as Lexiva and …
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Clinical Immunochemistry Analyzers Market projected reach USD 6.9 billion by 2034, growing at a CAGR of 4.4% | Exactitude Consultancy
13 Jun 2025 13:46 GMT
… 3CL Protease Inhibitor Market The global market for RdRp and 3CL protease inhibitors is … /rdrp-inhibitor-and-3cl-protease-inhibitor-market Aurora Kinase B ELISA …
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Secretory leukocyte protease inhibitor influences periarticular joint inflammation in B. burgdorferi-infected mice
17 Jan 2025 05:20 GMT
… inflammation16–19.
The secretory leukocyte protease inhibitor (SLPI) is a 12 kDa … by B. burgdorferi.
Secretory leukocyte protease inhibitor (SLPI) influences periarticular joint inflammation … )37. The lack of serine protease inhibitors, such as SLPI, can cause …
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FDA Approves Mavyret for Acute Hepatitis C
13 Jun 2025 13:52 GMT
… pill containing glecaprevir (an HCV protease inhibitor) and pibrentasvir (a NS5A inhibitor …
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Starton Therapeutics Announces Phase 2a Clinical Trial for Continuous Low-Dose Lenalidomide (STAR-LLD) in Multiple Myeloma Open for Enrollment
12 Jun 2025 20:01 GMT
… combination with dexamethasone and a protease inhibitor (PI) will be compared to …
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FDA Approves Glecaprevir/Pibrentasvir (Mavyret) Label Expansion for Acute HCV
12 Jun 2025 16:50 GMT
… (100mg), an NS3/4A protease inhibitor, and pibrentasvir (40mg), an NS5A …
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Adipose-Derived Mesenchymal Stem Cells Accelerate Diabetic Foot Ulcer Healing by Promoting Macrophage M2 Polarization Through Downregulation of EREG and CSTA
12 Jun 2025 15:41 GMT
… cells.57 CSTA, a cysteine protease inhibitor from the cystatin superfamily, likely … reveal a role for this protease inhibitor in cell-cell adhesion. Am …