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TL1A Binder Market Set to Expand by 2034 with Key Players Such as Merck, Roche, Teva Pharmaceuticals, Sanofi, and Others Driving Multi-Indication Advancements | DelveInsight
26 Sep 2025 00:41 GMT
… targets TL1A (TNFSF15), a central mediator of inflammation and fibrosis in … /SAR447189): Teva Pharmaceuticals/;Sanofi
List of drugs to be continued in …
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Investigating the Mechanism of Jiawei Weijin Decoction in Treating Non-Small Cell Lung Cancer Using Network Pharmacology, Bioinformatics Analysis and Experimental Validation
25 Sep 2025 08:23 GMT
… treatment, indicating that curcumol exerted pharmacological activity in inhibiting the migration … its role as a potential mediator of curcumol’s anti-tumor … uses on combination and versus drug therapies. Biomed Pharmacother. 2021;138:111350. doi:10 …
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Validate the Treatment of Crohn’s Disease with Chaihu Guizhi Decoction Through Network Pharmacology, Molecular Dynamics Simulation, and in vivo Experiments
23 Sep 2025 22:41 GMT
… (A) Pharmacological target of each drug component of CGD. (B) Drug-Target-Disease … . Through network pharmacology, we screen the effective components of drugs and their … IL-1 is a major mediator in the inflammatory environment and …
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Unlocking Typhonium flagelliforme’s Anti-Cancer Power via NEK7
26 Sep 2025 10:50 GMT
… ’s function as an essential mediator of the NLRP3 inflammasome complex … with optimal binding efficiencies and pharmacokinetic properties. The computational tools used … targets for rational drug design, allowing chemists and pharmacologists to optimize these …
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Single-Cell Transcriptomic Analysis Highlights the Impact of NFKB2-Mediated MIF-CD44 Signaling Axis in Endometrioid Endometrial Cancer
26 Sep 2025 10:57 GMT
… presence of the previously recognized drug resistance gene MIF, as … in cancer and inflammation. Drug Discov Today. 2021;26( … et al. CD44: a Multifunctional Mediator of Cancer Progression. Biomolecules. 2021 … syndrome? Eur Rev Med Pharmacol Sci. 2022;26(4): …
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Mexico’s Foreign Minister Juan Ramón de la Fuente Calls for End to Immigrant Criminalization and Trade War Tactics at United Nations General Assembly
26 Sep 2025 10:52 GMT
… Mexico, and measures to combat drug trafficking. In early 2025, Trump … intention to act as a mediator and bridge-builder in global … -19 pandemic, ongoing violence from drug cartels, and the need to …
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Crosstalk Between Cell Death and the cGAS-STING Pathway in Sepsis-Associated Acute Lung Injury
25 Sep 2025 22:52 GMT
… remain poorly understood, and effective pharmacological treatments are limited.7 Additionally … However, the inflammatory responses and mediator release associated with these processes … nanoparticulate systems for drug delivery. Nat Rev Drug Discov. 2014;13 …
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Proteomic Profiling of Serum-Derived Exosomes in Oral Lichen Planus: FN1-C3-ECM Crosstalk as a Potential Novel Therapeutic Target
25 Sep 2025 22:52 GMT
… topical anti-inflammatory or immunomodulatory drugs within the past 3 months … , including lichenoid contact reactions and drug-induced lichenoid eruptions.
Main Experimental … (ITGA2B and ITGB3), focal adhesion mediator (VCL), and TGF-β anchor (LTBP1 …
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Scientists Uncover EP2 Receptor’s Role in Pain, Not Inflammation
25 Sep 2025 17:49 GMT
…
Non-steroidal anti-inflammatory drugs, or NSAIDs, are among … which is considered a main mediator of inflammatory pain, in … responsible for pain. Delivering drugs locally to silence only … inflammation.
“Antagonism of this ‘druggable’ receptor would thus control …
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Discovery of EP2 receptor opens path to pain relief without blocking inflammation
25 Sep 2025 16:54 GMT
… which is considered a main mediator of inflammatory pain, in … responsible for pain. Delivering drugs locally to silence only … quot;Antagonism of this 'druggable'; receptor would thus control … especially with giving a drug systemically as a pill, …
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