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Treatment of Carbapenem-Resistant Gram-Negative Bacterial Infections with Polymyxins: A Review
02 Dec 2025 20:18 GMT
… Care Medicine, Zhongda Hospital, School of Medicine, … consequently, randomized controlled trials furnish the higher … a randomized control trial, treatment success was nonsignificantly … imipenem/cilastatin and imipenem/relebactam in the treatment …
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Diversity of Multi-Drug Resistance Genes in Escherichia coli Isolated from Poultry in Southern Togo
27 Nov 2025 10:28 GMT
… in the document stating that at least … clavulanic acid; 0% against carbapenems (imipenem, ertapenem) and polymyxins (colistin … human medicine, colistin has long been excluded from treatment protocols … Naturelles, École doctorale ED589. Thèse de Doctorat de l’ …
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Genomic and Phenotypic Characterization of Extensively Drug-Resistant Clinical Klebsiella quasipneumoniae subsp. similipneumoniae ST1929 Isolates
24 Nov 2025 15:45 GMT
… , ceftazidime, ceftazidime-avibactam, imipenem, meropenem, gentamicin, levofloxacin … revealing its extensive drug resistance, plasmid-mediated … Research of Kunming Medical University (Grant No … epidemiology, genetic context, treatment options, and detection …
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blaIMP-45 Amplification Facilitates Heterogeneous Resistance to Imipenem in Pseudomonas aeruginosa
10 Nov 2025 12:48 GMT
… into refractory infections and treatment failure.
Examination of … accordance with the medical research regulations of the … and therapeutic implications. Microb Biotechnol. 2024;17(5). … pharmacokinetics of meropenem and imipenem-cilastatin. Antimicrob Agents …
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Rapid Identification of Carbapenem-Resistant Klebsiella pneumoniae and Carbapenemase Genes via PTR-MS
12 Dec 2025 09:43 GMT
… using MEM alone, while different drug treatments did not significantly affect the … , and resistance spectra among various medical institutions, further verification of the … , New Delhi metallo-β-lactamase; IMP, imipenem hydrolysing MBL; RT, retention time; …
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<![CDATA[Oral Carbapenem Tebipenem HBr Demonstrates Non-Inferiority to IV Therapy in Phase III PIVOT-PO Trial]]>
22 Oct 2025 17:23 GMT
… randomized, double-blind PIVOT-PO trial (NCT06059846) compared oral tebipenem … with 60.2% for imipenem-cilastatin (adjusted treatment difference: −1.3%; … diseases at Sharp Rees-Stealy Medical Group. “The therapeutic … HBr data to the FDA in the fourth quarter …
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Medications for Gram-Negative Bacteria Infections and Complicated UTIs Show Promise
22 Oct 2025 17:04 GMT
… combinations.”
A phase 3 trial of tebipenem hydrobromide (HBr), … yielded positive results. The medication’s overall success rate “ … 2% for imipenem-cilastatin, for an adjusted treatment difference of … similar to that of imipenem-cilastatin and other carbapenems …
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GSK & Spero announce positive PIVOT-PO phase III trial of tebipenem HBr, an investigational oral treatment for complicated urinary tract infections
22 Oct 2025 12:40 GMT
… tebipenem HBr toward FDA submission and bringing … Diseases Sharp Rees Stealy Medical Group, commented: “Increasing … to patients and improving treatment options.”
Secondary endpoints … drug) in patients with qualifying pathogens susceptible to imipenem. The trial …
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<![CDATA[Oral tebipenem HBr matches IV carbapenem in phase 3 cUTI trial]]>
21 Oct 2025 21:45 GMT
… at Sharp Rees Stealy Medical Group, stated, “Increasing … patients and improving treatment options.”
Trial design and efficacy … imipenem-cilastatin (291/483 participants), with an adjusted treatment … and oral options for drug-resistant infections are limited …
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GSK reports positive trial data for oral cUTI treatment, secures EU backing for simplified shingles vaccine
21 Oct 2025 08:10 GMT
Drugmaker GSK made two key updates … Monday, with positive phase III trial results for tebipenem HBr, an … trial had demonstrated non-inferiority of oral tebipenem HBr versus intravenous imipenem …
Separately, GSK said the European Medicines Agency's CHMP had …