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<![CDATA[Imetelstat Improves Outcomes in Heavily Transfusion-Dependent MDS]]>
15 Dec 2025 22:42 GMT
… , MD, assistant professor of medicine at Harvard Medical School and at the … syndrome (MDS).
The IMerge trial investigated imetelstat vs placebo with best supportive … , they also benefited from the treatment with imetelstat. I think that…
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<![CDATA[FDA Grants Orphan Drug Designation to Roxadustat for Myelodysplastic Syndromes]]>
15 Dec 2025 20:25 GMT
… & Drug Administration (FDA) granted roxadustat an Orphan Drug Designation for the treatment of … from the Phase 3 MATTHERHORN trial, which, along with its … on current first-line treatments, including luspatercept, imetelstat, or lenalidomide, reach …
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Roxadustat Granted Orphan Drug Designation for the Treatment of Myelodysplastic Syndromes by the U.S. Food and Drug Administration
15 Dec 2025 13:24 GMT
… Drug Administration (FDA) has granted roxadustat Orphan Drug Designation for the treatment … agents (ESAs), luspatercept, imetelstat, or lenalidomide in lower … at the frontiers of cancer biology and anemia. … potential future clinical trials, and other matters …
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<![CDATA[Imetelstat as a Treatment Option for Low-risk MDS]]>
12 Dec 2025 14:26 GMT
… telomerase inhibitor, offers a novel treatment option for patients with low … beyond symptomatic anemia management. Conversely, imetelstat is generally avoided in patients … based on patient characteristics, prior treatment r
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Rigel Pharmaceuticals announces updated data from Phase 1b study of R2891
08 Dec 2025 01:43 GMT
Rigel Pharmaceuticals (RIGL) announced updated data from … agent and 6% had received imetelstat. 61% of patients were high … sideroblast negative. Median duration of treatment was 5.5 months. R289 …
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Blood Cancer Therapeutics Reach Critical Commercial and Clinical Inflection Points
04 Dec 2025 18:07 GMT
… tumor types including breast, lung, ovarian, pancreatic, bladder, and prostate cancers … #47;the-small-biotech-thats-cracking-the- … 3 IMpactMF clinical trial evaluating imetelstat in relapsed… recommended treatment option. The drug received full FDA approval …
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Myelodysplastic Syndrome Drugs Market is Projected to Increase at a CAGR of 9.3% Through 2025-2029
25 Nov 2025 00:00 GMT
… cancer survivors, and progress in clinical research and pharmaceutical … which includes medication that inhibits or … biotechnology firm based in the United States, introduced rytelo (imetelstat), an FDA …
1) By Immunomodulatory Drugs: Thalidomide, Lenalidomide, …
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Prognostic and Immunological Implications of Telomere Maintenance-Related Genes in Breast Cancer: A Mechanistic Exploration
12 Nov 2025 11:13 GMT
… role in the treatment of cancer.17 For instance, … combination of telomerase antagonist Imetelstat and trastuzumab can inhibit … RIPA buffer (P0013B, Beyotime Biotechnology, China) and 100× … drugs, which was related to the biological characteristics of the tumor …
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<![CDATA[Dr Gerds on Notable Ongoing Clinical Trials in Myelofibrosis]]>
21 Oct 2025 21:28 GMT
… Cancer Center; and a physician in the Department of Hematology and Medical … IMpactMF trial (NCT04576156) of imetelstat (Rytelo) for the treatment of … , luspatercept is already FDA approved for managing anemia … other randomized phase 3 trials are also ongoing, …
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<![CDATA[Managing Adverse Events for Patients With MDS Given Imetelstat]]>
14 Oct 2025 00:43 GMT
… , and assistant medical director of the Clinical Trials Office at Yale Cancer Center … notes that although imetelstat is an effective treatment for anemia in transfusion … patient is started on the drug, per the label, they should …