… study testing a novel y-secretase modulator (GSM) in amyloid-positive patients … Phase 2a study investigating the gamma-secretase modulator RG6289 (nivegacetor) in individuals at … effect of a new y-secretase modulator, RG6289, on CSF amyloid-ß peptides …

… s disease - Small molecule gamma-secretase modulators (GSMs) as promising disease … by gamma-secretase, a major limitation of first-generation gamma-secretase inhibitors … 39;s around highly current gamma-secretase modulators SOURCE: AlzeCure Pharma View …

… European Commission for its oral gamma secretase inhibitor as a monotherapy for … previously eligible for a CFTR modulator, according to Vertex. Alyftrek, made … the first once-daily CFTR modulator. The triplet drug met primary …

… to develop molecules that target gamma-secretase for the treatment and … first developed the concept of gamma-secretase modulators (GSMs), which preferentially reduce … molecule for better understanding how gamma-secretase contributes to AD pathogenesis. …

… symptoms through their effects on gamma-secretase—an enzyme complex that … than predicted based solely on gamma-secretase activity. By comparing all … development of targeted treatments. Modulators of gamma-secretase activity that promote the production …

… shown that using γ- Gamma Secretase Inhibitor (GSI) prevents … biologics (eg, selective γ-secretase inhibitors, DLL4-neutralizing antibodies) … of Notch pathway modulators in the treatment … TG, et al. Gamma-secretase inhibitor reduces allergic pulmonary …

… receive RG6289, Roche’s investigational gamma secretase modulator, an orally administered drug intended …

… receive RG6289, Roche’s investigational gamma secretase modulator, an orally administered drug intended …