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Advances and Challenges in Nano-Delivery Systems for Glioblastoma Treatment: A Comprehensive Review
04 Aug 2025 11:04 GMT
… US Food and Drug Administration (FDA)-approved for various … dendrimers functionalized with 5-fluorouracil,121 celecoxib-simvastatin dual … . Artif Cells Nanomed Biotechnol. 2020;48(1): … photothermal-chemotherapy treatment of glioblastoma. J Pharmaceut Sci. 2025 …
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Dr Sinicrope on the Clinical Implications of the ATOMIC Trial for Stage III dMMR CRC
01 Aug 2025 09:35 GMT
… Meeting, results from the trial demonstrated a statistically significant disease … (modified oxaliplatin, leucovorin, and fluorouracil) chemotherapy for this patient population … for potential inclusion in future treatment recommendations. With updated guidance, …
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FDA Grants Priority Review to Imfinzi for Early Gastric Cancers
29 Jul 2025 16:46 GMT
… and Drug Administration (FDA) will grant priority review to drug … and review of medicines that may treat … combined with FLOT chemotherapy (fluorouracil, leucovorin, oxaliplatin and docetaxel … between both treatment groups.
The MATTERHORN trial is studying …
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Histone Lactylation in Diseases: Regulation by Traditional Chinese Medicine and Therapeutic Implications
29 Jul 2025 15:25 GMT
… protein levels.87 Treatment using lactate dehydrogenase inhibitor drugs, such as oxamate … precise mechanisms underlying Chinese herbal medicine remains incomplete, primarily due to … enhances cell chemosensitivity to 5-fluorouracil in colorectal cancer cells. J …
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AstraZeneca’s Imfinzi granted FDA priority review to treat early-stage gastric cancer
29 Jul 2025 11:33 GMT
… the US Food and Drug Administration (FDA) to treat early- … the late-stage MATTERHORN trial, which has been evaluating … combination with standard-of-care fluorouracil, leucovorin, oxaliplatin and … with curative intent and treatment with neoadjuvant/adjuvant …
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US FDA grants priority review and breakthrough therapy designation to AstraZeneca's sBLA for Imfinzi to treat patients with resectable early─stage gastric and GEJ cancers
29 Jul 2025 05:43 GMT
… and Drug Administration (FDA) grants Priority Review to applications for medicines that … profile for Imfinzi and FLOT (fluorouracil, leucovorin, oxaliplatin, and docetaxel) … Phase III trial evaluating Imfinzi as perioperative treatment for patients with …
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Rethinking Oncology Trials With a Statistical Methodology That Puts Patients First
28 Jul 2025 19:44 GMT
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Incorporating NTB into trial design supports more … recent years, the pharmaceutical industry has increasingly adopted … ). Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon … in non‐inferiority trials. Statistics in medicine, 27(3), …
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Durvalumab Earns FDA Priority Review for Early-Stage Gastric Cancer
28 Jul 2025 19:41 GMT
… a critical unmet medical need where disease recurrence … patients.
The MATTERHORN trial protocol involved a perioperative … in combination with FLOT (fluorouracil, leucovorin, oxaliplatin, and … undergoing demanding perioperative treatment.1,2
Regulatory …
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FDA Grants Priority Review to Perioperative Durvalumab in Resectable Gastric/GEJ Cancer
28 Jul 2025 23:30 GMT
… (Imfinzi) for the treatment of patients with resectable, …
Notably, the Prescription Drug User Fee Act date … trial (NCT04592913), which evaluated the efficacy of neoadjuvant durvalumab plus FLOT (fluorouracil … use of immunosuppressive medication within 14 days …
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FDA Expedites Durvalumab Review for Resectable Early-Stage Gastric, Gastroesophageal Cancers
28 Jul 2025 23:05 GMT
… of Medicine. In combination with a chemotherapy regimen (fluorouracil, … from the MATTERHORN Trial
MATTERHORN investigators sought … multiple extensive phase 3 trials.
For patients with … McGovern G. FDA approves durvalumab for treatment of adult patients …