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Twice-a-year drug shows promise as statin alternative after slashing bad cholesterol levels by nearly 50%
17 Jun 2025 17:01 GMT
… in a recent multinational trial.
The drug targets a protein in … individuals who experience statin intolerance or struggle with daily medication adherence, addressing … primary endpoint.
The inclisiran treatment also outperformed ezetimibe, achieving a 35.4 …
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Is This Drug a Statin Alternative?
17 Jun 2025 08:43 GMT
… a monotherapy without statins remains uncertain.
… ezetimibe (P = .0002) by day 150.
Similar rates of treatment … direct comparison with statins, anti-PCSK9 monoclonal … trial, and another author reported serving as a consultant for multiple pharmaceutical …
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Early combination drug therapy slashes heart attack risk
14 Jun 2025 21:08 GMT
… single drug, a statin, and only adding another drug … trial.
They compared three groups of patients: those who got ezetimibe … )But the medication she studied—ezetimibe—has few … treatment plan, or algorithm, that helps doctors decide when to prescribe ezetimibe …
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MSD moves ahead in race to bring oral PCSK9 drug to market
10 Jun 2025 14:22 GMT
… trials show that when added to standard treatment with statins, … drugs.
CORALreef AddOn is testing enlicitide against other oral therapies, including ezetimibe … running another late-stage trial (CORALreef Lipids) in … already underway with the FDA.
"We think …
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Merck posts positive phase 3 trials results evaluating Enlicitide Decanoate in adults with Hyperlipidemia
10 Jun 2025 08:56 GMT
… a statin.
The CORALreef HeFH and CORALreef AddOn trials successfully … C for enlicitide versus ezetimibe, versus bempedoic acid … cardiovascular deaths. Despite available treatment options, cardiovascular-related … levels and will require medication to treat and …
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Enlicitide Reduces LDL-C in People With Hyperlipidemia, HeFH, Against Placebo and Non-Statins
09 Jun 2025 20:30 GMT
… , including at least a statin. In addition to meeting … safety of enlicitide compared to ezetimibe, to bempedoic acid, … MD, Professor of Medicine at Baylor College of Medicine, added.1 … 3-CORALreef-Trials-Evaluating-Enlicitide-Decanoate-for-the-Treatment-of- …
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Merck reports positive results from the first two phase 3 CORALreef trials of enlicitide decanoate to treat adults with hyperlipidemia
10 Jun 2025 04:34 GMT
… a statin. The CORALreef HeFH and CORALreef AddOn trials successfully … C for enlicitide versus ezetimibe, versus bempedoic acid … cardiovascular deaths. Despite available treatment options, cardiovascular-related … levels and will require medication to treat and …
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NewAmsterdam Pharma Announces Positive Topline Alzheimer’s Disease Data from BROADWAY Clinical Trial
09 Jun 2025 11:00 GMT
… developing oral, non-statin medicines for patients at risk … treatments. In each of the Company’s Phase 2 trials … fixed-dose combination with ezetimibe, have been exclusively … Italy-based, leading international pharmaceutical and diagnostics company. About …
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Merck's Cholesterol Lowering Drug Hits Primary Goal In Two Pivotal Trials
09 Jun 2025 18:44 GMT
… of three Phase 3 clinical trials evaluating the safety and … adverse events (SAE) in either trial.
Also Read: Merck’s … and are treated with a statin.
CORALreef AddOn: Statistically significant … LDL-C for enlicitide versus ezetimibe, versus bempedoic acid and …
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Merck claims study success with PCSK9 cholesterol pill
09 Jun 2025 17:55 GMT
… therapies, such as ezetimibe, in people on statins and with abnormally … lowering pill medicine on the market, and the foundation for future drug … scrutinized. In Phase 2 trials, a variety of enlicitide … 60% after eight weeks of treatment. One of the Phase …
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