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27 Elacestrant vs Standard of Care in ER+, HER2- Advanced or Metastatic Breast Cancer With ESR1-Mutated Tumors: ESR1 Allelic Frequencies and Clinical Activity From the Phase 3 EMERALD Trial
19 Jun 2025 23:08 GMT
Background
The phase 3 EMERALD trial (NCT03778931) reported significantly prolonged progression- … +)/HER2-negative (HER2–) metastatic breast cancer (mBC) and tumors harboring ESR1 … /AKTi, chemotherapy, or antibody-drug conjugate-based regimens.
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Why I Don’t Call Myself a Survivor With Metastatic Breast Cancer
19 Jun 2025 19:25 GMT
… metastatic breast cancer, she admitted she only knew of it from the pharmaceutical … breast cancer can affect anyone at any time, even years after successful treatment … . 30% of early-stage breast cancer will come back …
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Health Canada Approves Adjuvant Ribociclib for HR+/HER2– Early Breast Cancer
19 Jun 2025 19:32 GMT
… to the most effective treatment options, and their … with early breast cancer in Canada.”
NATALEE Trial Overview and … patient-reported outcomes, and pharmacokinetics.
Additional Efficacy and Safety … Med. 2024;390(12):1080-1091.doi:10.1056/NEJMoa2305488
FDA …
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Dr Tarantino on the Evolving Role of THP in HER2+ Metastatic Breast Cancer
19 Jun 2025 19:31 GMT
… (THP) in HER2-positive metastatic breast cancer following the readout of data … 3 DESTINY-Breast09 trial (NCT04784715).
In the current landscape, treatment decisions are … repositioned within a more tailored treatment paradigm. As sequencing strategies evolve …
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Breaking Down the Impact of SERENA-6 for Some With Breast Cancer
19 Jun 2025 19:25 GMT
… breast cancer treatment. During the interview, McGuinness highlighted the SERENA-6 trial … treatment is a combination of an aromatase inhibitor (an anti-estrogen medication … reviewed by the FDA before we can … breast cancer, so we'd first need drug …
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Pharma Pulse 6/19/25: Strategic Planning in the Rebate Economy; The Truth About AI Adoption Speed in Clinical Research
19 Jun 2025 19:58 GMT
… the NIH and FDA—is quietly leading … Medicine Oncology Pharmacist
Precision medicine oncology pharmacists are playing … safer, more effective treatment as precision oncology continues … clinical practice.
How Firsthand Breast Cancer Experience Shaped a Surgeon …
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T-DXd May Be the Preferred ADC in HR+/HER2– Breast Cancer
19 Jun 2025 15:11 GMT
… patients with triple-negative breast cancer (TNBC), extensive data … having both antibody-drug conjugates [ADCs] as treatment options for … we’re giving these drugs to, we have to … breast cancer (TROPiCS-02): a randomised, open-label, multicentre, phase 3 trial …
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FDA Updates Talzenna-Xtandi Label for HRR-Mutated Metastatic Prostate Cancer
19 Jun 2025 19:26 GMT
The U.S. Food and Drug Administration (FDA) approved updated labeling for Talzenna … phase 3 TALAPRO-2 trial evaluated treatment for metastatic castration-resistant … single treatment for adults with HER2-negative locally advanced or metastatic breast cancer …
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Timing of ESR1 Mutation Testing Is Critical to Overcome Adaptive Endocrine Resistance in HR+ Breast Cancer
19 Jun 2025 13:49 GMT
… different options available [after treatment with an] AI … hormone receptor–positive breast cancer whose progression is … placebo-controlled trial, patients were taking 3 pills. They were … breast cancer (ABC): Phase 3, double-blind ctDNA-guided SERENA-6 trial …
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New three-shot breast cancer vaccine offers new hope, targets milk protein to stop tumours before they grow
19 Jun 2025 13:34 GMT
… aggressive types of breast cancer, particularly triple-negative breast cancer. Unlike traditional vaccines … an early phase one clinical trial” to explore a promising … crucial in triple-negative breast cancer, where treatment options are limited due …