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<![CDATA[Blinatumomab Boosts Survival in Pediatric ALL, but Faces Delivery Hurdles]]>
14 Dec 2025 18:09 GMT
… treatment by demonstrating that the improved outcomes associated with blinatumomab persist.
The trial … newly diagnosed with National Cancer Institute standard risk … used in COG trials. In the control … of the FDA approval of blinatumomab, the researchers …
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<![CDATA[Other Possible Research Avenues for Blinatumomab in ALL]]>
12 Dec 2025 16:02 GMT
… , explore future research directions for blinatumomab in ALL, including combination strategies … immunotherapies and evolving MRD-driven treatment paradigms may shape upcoming clinical …
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<![CDATA[Dr Patel on the Feasibility of Outpatient Treatment in Ph+ ALL]]>
11 Dec 2025 00:33 GMT
… treatment, which are often associated with other regimens like TKI plus blinatumomab … CD22+ on ≥20% of blasts. Treatment evolved from schema 1 to …
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<![CDATA[Blinatumomab/Ponatinib Provides Chemo-Free Option in Ph+ ALL]]>
07 Dec 2025 19:31 GMT
… of ponatinib (Iclusig) plus blinatumomab (Blincyto) vs imatinib (Gleevec … 9% of patients were off treatment (P = .004). These … further meetings of this treatment regimen, including:
BCR:: … GIMEMA ALL2820 trial comparing ponatinib plus blinatumomab to imatinib …
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Chemotherapy-free combination treatment outperforms traditional regimens in patients with Ph+ ALL
08 Dec 2025 02:49 GMT
… study. The phase III trial, which included adult … and chemotherapy.
For the trial, researchers enrolled 236 adult … cycles of the immunotherapy blinatumomab. Patients in the control … continue working while undergoing cancer treatment.
A separate study is …
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<![CDATA[Dr Goulart on the Efficacy of Frontline Blinatumomab Plus Ponatinib in Ph+ B-ALL]]>
07 Dec 2025 14:27 GMT
… patients achieved a response [with blinatumomab plus ponatinib].”
Hannah Goulart, MD … University of Texas MD Anderson Cancer Center, discussed long-term follow … a phase 2 trial (NCT03263572) investigating first-line blinatumomab (Blincyto) plus ponatinib …
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Studies Point to a Growing Role for New Therapies and Immunotherapies in Treating Blood Cancers
07 Dec 2025 13:11 GMT
… Brigham Cancer Institute and associate professor of medicine at Harvard Medical School … new trial, patients with follicular lymphoma had a significantly higher response to treatment … U.S. Food and Drug Administration (FDA) approved epcoritamab with rituximab …
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<![CDATA[Pediatric and AYA B-ALL Treatment Effective Without Total Body Irradiation]]>
06 Dec 2025 17:58 GMT
… primary end point of the trial of EFS was met.
… were enrolled in the trial. The treatment arm (51 patients) … Blincyto (blinatumomab) was allowed. Patients were excluded from the treatment arm … Blood.
For more news on cancer updates, research and education, …
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<![CDATA[Role of Age and Ph Status in Blinatumomab Selection in ALL]]>
05 Dec 2025 20:45 GMT
… decision to incorporate blinatumomab (Blincyto) into an ALL treatment plan. They discuss … based on disease biology and treatment tolerance. They also outline how … these factors guide personalized treatment algorithms and optimize therapeutic outcomes …
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First AACR pediatric cancer report notes progress, unmet needs
04 Dec 2025 20:22 GMT
… cancer treatments, which include more than 30 combined FDA … (94.7%), Burkitt lymphoma (91.1%) and … (Kymriah, Novartis) and blinatumomab (Blincyto, Amgen) for ALL … because pharmaceutical companies often shy away from pediatric cancer-specific trials. …