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U.S. FDA approves AKEEGA® as the first precision therapy for BRCA2-mutated metastatic castration-sensitive prostate cancer with 54% reduction in disease progression vs standard of care*
13 Dec 2025 01:56 GMT
… AKEEGA® plus prednisone and androgen deprivation therapy (ADT) significantly reduced … formulation with prednisone plus androgen deprivation therapy (ADT) compared to matching … still responds to hormone therapy (androgen deprivation therapy).3 While the …
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<![CDATA[FDA Approves Targeted Combination Therapy for BRCA2-Mutated Prostate Cancer]]>
13 Dec 2025 01:28 GMT
… participants continued to receive concurrent androgen deprivation therapy (ADT).2,3
The major … efficacy for the new combination therapy. For this subgroup, the hazard …
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J&J positions its PARP combo Akeega in new prostate cancer subset with 2nd FDA nod
16 Dec 2025 00:48 GMT
… J&J’s androgen-directed prostate cancer med … that a PARP inhibitor-androgen receptor pathway inhibitor treatment … Amplitude, Akeega plus prednisone and androgen deprivation therapy (ADT) cut the risk … and ADT. The combo therapy also extended the time to …
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J&J gains label expansion approval for Akeega in mCSPC
15 Dec 2025 17:51 GMT
… and J&J’s androgen inhibitor, Zytiga (abiraterone) in … that Akeega plus prednisone and androgen deprivation therapy (ADT) cut the … the use of an androgen receptor signalling inhibitor such … approval for use alongside androgen receptor inhibitor Pfizer and …
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<![CDATA[Evaluating Long-Term ARPI Clinical Trial Data in mCSPC]]>
15 Dec 2025 14:31 GMT
… from pivotal trials evaluating androgen receptor pathway inhibitors (ARPIs … these studies, combination therapy with ARPIs and androgen deprivation therapy (ADT) consistently … effective, particularly in triplet therapy. Panelists concluded that extended …
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Johnson & Johnson Wins FDA Nod For First Precision Combo For Mutated Prostate Cancer
15 Dec 2025 14:38 GMT
… with Akeega plus prednisone and androgen deprivation therapy (ADT) significantly reduced the risk …
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<![CDATA[Stage 3 Prostate Cancer: A Guide to Diagnosis, Treatment, and Next Steps ]]>
14 Dec 2025 19:50 GMT
… on male hormones to grow. Androgen-deprivation therapy (ADT) works by lowering the … before, during, and after radiation therapy (neoadjuvant, concurrent, and adjuvant ADT …
Managing Side Effects: Radiation, Hormone Therapy, and Surgery
Treatment side effects …
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JnJ bags USFDA nod for Akeega plus prednisone for BRCA2 mutated metastatic castration sensitive prostate cancer
14 Dec 2025 10:27 GMT
… a PARP inhibitor with an androgen receptor pathway inhibitor delays both … with AKEEGA plus prednisone and androgen deprivation therapy (ADT) significantly reduced the risk …
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<![CDATA[FDA Approves Niraparib/Abiraterone Combo for BRCA2-Mutated mCSPC]]>
13 Dec 2025 03:49 GMT
… the use of the combination therapy specifically to patients with BRCA2 … daily. All patients also received androgen deprivation therapy (ADT).1,2
In the …
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<![CDATA[FDA Approves Niraparib Regimen in BRCA2+ Metastatic CSPC]]>
12 Dec 2025 23:50 GMT
… ; all were assigned to receive androgen deprivation therapy.
Topline data showed that among …
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