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Screening mRNA Therapeutics with Protein Barcoding
03 Jul 2025 15:08 GMT
… acid-based therapeutics, including antisense oligonucleotides (ASO), small interfering RNA (siRNA), messenger … protein barcodes, which are genetically encoded short amino acid sequences … , Xu H. Nucleic acid drugs: recent progress and future perspectives …
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RNA: Searching for druggable targets
02 Jul 2025 19:07 GMT
… genetic material, making their RNA sequences a potential target for antiviral drugs … not effective drug targets. PEDV: porcine epidemic diarrhea virus; siRNA: small interfering … , selective, and safe RNA-targeting drugs. The opportunities are plenty, and …
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Platelet Membrane-Coated Poly (Lactic-Co-Glycolic Acid) Nanoparticles as a Targeting Drug Delivery System for Multidrug-Resistant Breast Cancer
01 Jul 2025 22:18 GMT
… 1:1000 dilution; Santa Cruz Biotechnology, Inc., Dallas, TX, USA … 1:1000 dilution; Santa Cruz Biotechnology, Inc., Dallas, TX, … and sustained drug release effectively improves intracellular drug delivery, overcoming … paclitaxel and PD-L1 siRNA. Int J Pharm. …
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Emerging Trends in the Application of Nanosuspension-Based Biomaterials for Anticancer Drug Delivery
01 Jul 2025 12:03 GMT
… throughout the formulation process. Drug molecules or genetic material can be integrated … genetically engineered surface modification makes it appropriate for a variety of drug … co-delivering paclitaxel and survivin siRNA to enhance antitumor outcomes. Int …
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Sirius, CRISPR Ink Development Deal
16 Jun 2025 12:00 GMT
… the company’s clinical-stage drug candidates.
“Certainly that … standard small molecule-based drugs may target a protein … functions within a cell, siRNA therapeutics can effectively halt the production … backed equity, other big pharma monies or some other …
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Challenges and Solutions in Oligonucleotide Analysis (Part 2): An HPLC 2025 Video Interview with Torgny Fornstedt
04 Jul 2025 15:14 GMT
… the realm of oligonucleotide-based drugs—analytical scientists face mounting challenges … reliable analysis and purification of drug molecules using high-pressure … siRNA) and digital technology applications for quality assurance of next-generation drugs.
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Distinct Lung Adenocarcinoma-Associated Microbiota Are Associated with Inflammatory Immune Landscapes and Tumor Cell Proliferation via LCIIAR–ISG15 Regulatory Networks
04 Jul 2025 14:41 GMT
… median as the cutoff point.
siRNA-Mediated Gene Knockdown and Quantitative … varying bacterial abundances, suggested possible genetic mechanisms underlying these associations.
Figure … its expression (Figure 6C), and siRNA-mediated knockdown of ISG15 similarly …
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The Toxicity of Dimethyl Sulfoxide Combined with the Alkylating Agent MNU on Mice: Focusing on Mortality and Activity Impairment
04 Jul 2025 14:41 GMT
… in laboratory experiments, particularly in drug delivery systems and pharmacological studies … of absorption, metabolism, or individual genetic responses, might influence the observed … vesicles-mediated delivery of Cul7 siRNA for retinal degeneration therapy. …
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Aptamer raises £2m to support expanding its Optimer technology
04 Jul 2025 12:31 GMT
… AI-driven models to improve drug candidate selection using the company … June liver fibrosis breakthrough in siRNA delivery had drawn strong industry …
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Glial betaPix is essential for blood vessel integrity in the zebrafish brain
03 Jul 2025 23:59 GMT
… gain insights into the genetic basis and pathophysiological mechanisms … us to decipher the genetic basis of ICH in … with negative control siRNA or betaPIX siRNA separately, in combination … Automated Cell Counter (Countstar BioTech). Single cells were barcoded …