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Repurposed Diabetes Drug Primes CAR T-Cell Therapy Cancer Targets
17 Sep 2025 09:11 GMT
… The first FDA-approved antibody-drug conjugate therapy … patients whose malignancy is treatment resistant, meaningful improvement … repurposed older diabetes drugs, including rosiglitazone and pioglitazone, both of … led by former UCSF medical student Kevin Chang, …
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CYP2C8-Mediated Drug–Drug Interactions and the Factors Influencing the Interaction Magnitude
16 Sep 2025 09:22 GMT
… diabetes who had no history of hypoglycemia received repaglinide treatment … to comedicate with statins.85
Antidepressants
Fluvoxamine is … and clinical pharmaceutical care. Develop new drugs that … of CYP2C8 substrate pioglitazone. Drug Metab Dispos. 2016 …
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Repurposed diabetes drugs boost CAR T therapy effectiveness in bladder cancer
13 Sep 2025 02:33 GMT
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The first FDA-approved antibody-drug conjugate therapy … patients whose malignancy is treatment resistant, meaningful improvement … old class of diabetes drugs – rosiglitazone and pioglitazone – which stimulate … led by former UCSF medical student Kevin Chang, …
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Obesity and Its Comorbidities: Current Treatment Options, Emerging Biological Mechanisms, Future Perspectives and Challenges
11 Sep 2025 19:59 GMT
… and pioglitazone are clinically used as promising drug … Food and Drug Administration (FDA) approved five medications for long … for the treatment of type 2 diabetes mellitus. Diabetes. 2009 … placebo-controlled, multicentre clinical trial. Trials. 2023;24:283. …
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Study challenges conventional thinking about the onset of Type 2 diabetes
11 Sep 2025 17:17 GMT
… , MD, professor of medicine and chief of the Diabetes Division at the … effective treatments for Type 2 diabetes, prediabetes and potentially pre-prediabetes. One drug … DeFronzo champions is the insulin sensitizer pioglitazone, which has …
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Repurposing a Diabetes Medication to Prime CAR T Cancer Targets
10 Sep 2025 23:23 GMT
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The first FDA-approved antibody-drug conjugate therapy for … whose malignancy is treatment resistant, meaningful improvement … old class of diabetes drugs – rosiglitazone and pioglitazone – which … reflecting the latest medical knowledge, advanced technologies …
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Exploring the Antidepressant Potential of GLP-1 Receptor Agonists
10 Sep 2025 17:48 GMT
… diabetes.2
Over the years, various classes of medications … from 5 randomized controlled trials and 1 prospective … control treatments, whereas another meta-analysis reported that pioglitazone … systematic review of the antidepressant effects of glucagon-like …
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‘I am 35, just diagnosed with type 2 diabetes. The doctor prescribed Metformin twice a day. I am afraid of taking it. Is there any substitute or other solutions to lower sugar level?’
10 Sep 2025 04:41 GMT
… medications for diabetes, but each comes with its own pros and cons. Doctors … ) and Victoza (liraglutide) are injectable drugs that mimic a natural hormone … hypoglycemia, while thiazolidinediones like Actos (pioglitazone) improve insulin sensitivity but can …
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Clinical Outcomes and Complications of Basal, Bolus, and Combination Insulin Regimens in Type 2 Diabetes Mellitus: Evidence from Published Case Reports
02 Sep 2025 16:45 GMT
… evolution of diabetes treatment guidelines, this … Treatment involved insulin adjustment, oral antidiabetic drugs, antihypertensive medication … on metformin, repaglinide, pioglitazone, and insulin detemir … term antihypertensive and statin (atorvastatin) therapy …
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Effects of Brown Rice, Meal Replacements, and Anti-Obesity Drugs on Mitochondria in Obese Rats
01 Sep 2025 13:24 GMT
… TZDs such as pioglitazone exert beneficial effects on … Laboratory, Faculty of Medicine, Universitas Brawijaya.
Gut … mitochondria interactions. Clinical trials translating these preclinical insights … replacement treatment of obesity-related type 2 diabetes. J …