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Identification of Core SASP-Related Genes TGFBI and ANXA6 for Diagnosing Ulcerative Colitis-Related Colorectal Cancer Through Machine Learning
17 Sep 2025 17:46 GMT
… , differentially expressed genes; WGCNA, weighted gene co-expression network … genes were significantly enriched in pathways, such as viral protein … and cytokine receptor, protein digestion and absorption, … associated with accumulation of p53 and p16INK4a. Cell. …
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CRISPR activation for SCN2A-related neurodevelopmental disorders
17 Sep 2025 17:19 GMT
… -induced protein 44 and interferon-induced protein 44- … transcriptionally activated by p53 suppresses hedgehog signaling. … dCas9-based Scn1a gene activation restores inhibitory … Postnatal therapeutic approaches in genetic neurodevelopmental disorders. Neural …
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Elicio Therapeutics Reports ELI-002 7P Achieved Robust mKRAS-Specific T Cell Responses in 99% of Evaluable Patients in Ongoing Phase 2 AMPLIFY-7P Trial
17 Sep 2025 12:00 GMT
… were administered ELI-002 7P generated strong mKRAS-specific T cell … by mutations in the KRAS-gene—a prevalent driver of many … by latching on to the protein albumin, found in the local … target BRAF-driven cancers and p53 hotspot mutations, respectively. For …
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Dermatotoxicity of Immune Checkpoint Inhibitors in Advanced Non-Small Cell Lung Cancer: Current Advances in Mechanistic Insights and Predictive Biomarker Identification
17 Sep 2025 09:09 GMT
… Reactivity
Beyond genetic predisposition, numerous irAEs are … networks—from genetic alterations to immune-microbiome crosstalk … , lymphocyte-specific protein tyrosine kinase; LAG-3, Lymphocyte Activation Gene-3; TIGIT, … role for p53 in regulating cancer cell-intrinsic …
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Association Between Human Papillomavirus and Thymic Cancer: A Population-Based Cohort Study
17 Sep 2025 09:09 GMT
… as exploratory and hypothesis-generating only, and should be … observed decreased expression of p53, a tumor suppressor, … vesicles containing nucleic acids, proteins, and noncoding RNA, potentially … polymerase chain reaction-based genechip method in cervical …
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Can poor sleep increase cancer risk? Oncologist shares 6 silent factors that are harming you
17 Sep 2025 09:06 GMT
… light exposure interfere with circadian genes (CLOCK, BMAL1, PER, CRY) … taxa such as Fusobacterium nucleatum, generates genotoxins like colibactin, maintains mucosal … ) that also inactivate tumor suppressor proteins (p53 and Rb), change epigenetics, and …
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Population Pharmacokinetic/Pharmacodynamic Modeling of Tacrolimus in Renal Transplant Recipients: Impact of CYP3A5 Genotype and Wuzhi Capsule Co-Medication
16 Sep 2025 09:23 GMT
… medical records. CYP3A5 gene categories and laboratory test … equation for tacrolimus using genetic variants and clinical factors … Miljković B. Total plasma protein effect on tacrolimus elimination … induces apoptosis and p53 mobilization to mitochondria in …
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Study uncovers DNA flaw behind cancer treatment responses
15 Sep 2025 12:22 GMT
… in cancer treatment.”
A gene-editing technology could help … in cells missing p53, another key protective gene often lost … the researchers developed rapid protein degradation technologies and teamed … 6-RB signalling and chemical genetics. Nat Commun 16, 8268 …
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Effects of Clinacanthus nutans Extracts on Cell Proliferation and Apoptosis in Triple-Negative Breast Cancer: Mechanistic Insights
15 Sep 2025 07:09 GMT
… using genes corresponding to differentially expressed proteins. Relevant … Transcription Factor; PPI, Protein-Protein Interaction.
GO Enrichment Analysis … and downregulated proteins, respectively. These proteins are … HXK2 in both p53-dependent and independent …
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Linking Brain and Immune Transcriptomes to Gut-Derived Metabolites in Hepatic Encephalopathy: An Explorative Integrative Multi-Omics Approach
15 Sep 2025 07:08 GMT
… Processing of Target Genes
The Gene Expression Omnibus (GEO … genes in each dataset.
After searching GeneCards for genes … HE-related genes. Reconstructed miRNA-gene interaction networks … liver fibrosis through a P53 proteins signaling-dependent manner. …