… The tumor suppressor protein p53 plays an indispensable … making the altered p53 protein prone to rapid … p53 Y220Crestoring p53 functionsmall molecule therapiestargeted cancer treatmentsthermolabile proteins in cancerTP53 gene mutationstumor suppressor protein …

The gene p53 acts as a tumor suppressor … ‘guardian of the genome.’ This gene is central to maintaining genomic … the ability to grow aggressively. Gene p53 is mutated in about 50% … Lin FT, Lin WC. Mutant p53 variants differentially impact replication initiation …

… type 2 diabetes-related genes (GeneCards) were screened. A … network of key genes in EC. (A) Protein-protein interaction (PPI) … ) with T2DM-associated genes from GeneCards. Through a comprehensive … features and impact of p53 status on sporadic mismatch …

… of hyperlipidemia with the gene-editing therapy targeting APOC3. … have shown that the APOC3 protein, produced in the liver … safety risks such as p53 activation, chromosomal damage, … . Its robust pipeline spans genetic disorders, metabolic diseases, and …

… * progression elif gene in PATHWAY_DB['p53_Signaling']['genes';]: trans[i, start_idx: … ', gene, protein, gene_fc, prot_fc)) for pathway, content in PATHWAY_DB.items(): if gene in content['genes';]: for metab in content[…

… CI, 0.63-2.79; P = .53). Investigators did note that at … resection. The HER2DX assay generated risk and pCR scores stemming … from 4 predefined gene expression signatures that encompass 27 … genes in order to provide …

… to P22.7 million from P53.6 million last year as … stores as of end-September. General and administrative expenses rose 11 …

… Policy Board (GPPB) OIC- Director General Atty. Sofia Yanto-Abad, PhilHealth … and Ambulatory Service (BUCAS) centers, P53.3 billion for PhilHealth’s …

… type of stem cell that generates melanocytes, the pigment-producing cells … in vivo lineage tracing and gene expression profiling in mice, the … controlled by activation of the p53–p21 pathway. Genotoxic insults drive …

… signal. Evorpacept is a fusion protein, and it’s designed to … and third line evorpacept data generated in patients with high CD47 … models harboring KRAS, BRAS and p53 mutations. ALX2004 shows excellent tumor …