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Cornus officinalis Protects Against Steroid-Induced Osteonecrosis of the Femoral Head Through Inhibiting Inflammatory Responses and Apoptosis via Network Pharmacology and Experimental Validation
08 Jul 2025 20:35 GMT
… of candidate targets via protein–protein interaction (PPI) analysis … , steroid binding, p53 binding. The top … GeneCards: integrating information about genes, proteins and diseases. Trends Genet. … 2017: quality-controlled protein-protein association networks, …
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Multi-Omics Analysis and Validation of Cell Senescence-Related Genes Associated with Non-Alcoholic Fatty Liver Disease
04 Jul 2025 14:40 GMT
… genes extracted at the methylation, gene expression and protein … Gene Methylation on Gene Expression
We did not identify common proteins between intersecting genes … methylation, gene expression and protein abundance … as tumor protein p53 inducible protein 3, …
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Building a BioCypher-Powered AI Agent for Biomedical Knowledge Graph Generation and Querying
03 Jul 2025 11:57 GMT
… ;inflammation"],
"proteins": ["p53", "EGFR… their interactions through randomly generated but biologically meaningful relationships. … _genes:
disease_genes[disease] = []
disease_genes[disease].append(gene)
return disease_genes
…
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Trailbreaker Acquires the Wheaton Gold Property, an Orogenic Gold Prospect in BC's Underexplored Turnagain Placer District
07 Jul 2025 14:39 GMT
… Economic Geologists Special Publication 17, p. 53–109.
Cassiar Gold website
https … assumptions, including the assumption that general business and economic conditions will …
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Distinct Lung Adenocarcinoma-Associated Microbiota Are Associated with Inflammatory Immune Landscapes and Tumor Cell Proliferation via LCIIAR–ISG15 Regulatory Networks
04 Jul 2025 14:41 GMT
… Kras mutation and p53 deletion significantly suppressed … differentially expressed genes (DEGs), generating protein interaction networks … TME signature genes, immune checkpoint genes, and viral … abundances, suggested possible genetic mechanisms underlying these …
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Basal Metabolic Rate Influences Liver Cancer Progression
03 Jul 2025 10:39 GMT
… . By examining animal models genetically selected for divergent BMR levels … functional expression of p53 and adenomatous polyposis coli (APC) proteins. The diminished … transformation. Such perspectives may generalize across other cancers where metabolism …
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Impact of Di-(2-Ethylhexyl)-Phthalate on Metabolic Syndrome: Insights from Network Toxicology and Molecular Docking and Dynamics
08 Jul 2025 10:35 GMT
… MetS-related target genes in the GeneCards database (https:… list of disease targets.
Protein–Protein Interaction (PPI) Network … the core targets of Tumor Protein p53 (TP53), Estrogen Receptor … The TP53 gene encodes the tumor suppressor protein p53 and is …
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Ascentage Pharma Appoints Dr. Veet Misra as Chief Financial Officer and Eric Huang as Senior Vice President of Global Corporate Development and Finance
07 Jul 2025 23:30 GMT
… proteins in the apoptotic pathway, such as Bcl-2 and MDM2-p53 … and next-generation kinase inhibitors. The lead … is the first novel third-generation BCR-ABL1 inhibitor approved in … intolerant to first and second-generation TKIs. It is covered …
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CYCLACEL PHARMACEUTICALS HIGHLIGHTS PUBLICATION OF PRECLINICAL DATA SHOWING THAT PLOGOSERTIB IS ACTIVE IN A HARD-TO-TREAT SUBTYPE OF LIVER CANCER
07 Jul 2025 10:00 GMT
… poor at approximately 30%. The protein kinase A (PKA) enzyme … of the DNAJB1 and PKAc genes. FCF funded research at … Rockefeller University identified this unique gene fusion in 2014 located … In general, cancer cells, and in particular KRAS mutated and p53(- …
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Glioma-Associated Mesenchymal Stromal/Stem Cells Derived Exosomal miR-191 Promotes the Proneural-to-Mesenchymal Transition in Glioblastoma Cells via PTEN/PI3K/AKT Signaling
07 Jul 2025 04:57 GMT
… cargo, which comprises proteins, nucleic acids, and … overexpression also upregulates the protein levels of mesenchymal markers … changes, including alterations in gene expression, signaling pathways, … modulating the TET1-p53 pathway in intrahepatic …
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