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Big fat problem: Why 'eat less, move more' mantra might not always work to fight obesity
11 Jul 2025 13:28 GMT
… people that are overweight or obese costs the UK
£126 billion … .
We now understand that
obesity is multifactorial. Genetics, childhood experiences, cultural norms … a Fitbit and salad.
obesity is multifactorial. Genetics, childhood experiences, cultural norms …
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Gene Editing Unlocks DIY Weight-Loss Drug Delivery
10 Jul 2025 11:05 GMT
… genetics. That complexity makes them hard to treat using traditional gene … obesity don’t have a clear genetic target, limiting what current gene … more closely mimic human obesity. The researchers also … diet-induced non-genetic obesity and pre-diabetes. Comms …
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Targeted Adipose Changes in Obesity, Weight Loss
10 Jul 2025 06:34 GMT
… of a common gene signature comprising 188 upregulated genes. This multicellular stress … for unraveling the pathophysiology of obesity-related adipose dysfunction. Moreover, … unlock novel approaches to managing obesity and its associated comorbidities, …
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Methyl Donor Intake, Parental Obesity Linked to Obesity Risk
09 Jul 2025 21:27 GMT
… phenotypic outcomes such as obesity. Beyond individual genes, methylation patterns modulated by … multi-layered condition influenced by gene-diet-environment interconnections. Teixeira and …
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Obesity care: why “eat less, move more” advice is failing
09 Jul 2025 13:06 GMT
… that are overweight or obese costs the UK £126 … now understand that obesity is multifactorial. Genetics, childhood experiences, cultural … socioeconomic factors in shaping obesity risk. And this … Nice guidelines and the Obesity Health Alliance’s recommendations …
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Obesity Reversed in Genome Edited Mice that Produce Their Own GLP-1
09 Jul 2025 13:03 GMT
… its therapeutic application in obese mice. [Keiichiro Suzuki] … pivoted from fixing faulty genes to installing entirely new … the engineered Exendin-4 gene, allowing efficient targeting of … chronic, multifactorial conditions like obesity and type II diabetes …
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Rhythm Pharmaceuticals Announces Oral MC4R Agonist Bivamelagon Achieved Statistically Significant, Clinically Meaningful BMI Reductions in Placebo-controlled Phase 2 Trial in Acquired Hypothalamic Obesity
09 Jul 2025 12:00 GMT
… call. About Acquired Hypothalamic Obesity
Acquired hypothalamic obesity is a rare form … in POMC, PCSK1, or LEPR genes that are interpreted as pathogenic … genetic syndromes and general (polygenic) obesity
Contraindication Prior serious hypersensitivity to …
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Early knee damage in 30s: Symptoms to watch, what causes it, and ways to prevent
10 Jul 2025 05:06 GMT
… due to factors like obesity, blood pressure, and genetics. As knee issues … osteoarthritis, your risk increases significantly. Genetics can influence cartilage strength and …
While some risk factors like genetics can’t be changed, several …
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Rhythm Pharmaceuticals Presents Data on MC4R Agonists Setmelanotide and Bivamelagon at ENDO 2025
12 Jul 2025 22:00 GMT
… Professor, Pediatric Endocrinology and Molecular Genetics, Department of Pediatrics, Columbia University … , MA. About Acquired Hypothalamic Obesity
Acquired hypothalamic obesity is a rare form … in POMC, PCSK1, or LEPR genes that are interpreted as pathogenic …
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Mechanisms of Microctis Folium in Hyperlipidemia: Integrating Serum Pharmacochemistry, Network Pharmacology, and Transcriptomics
11 Jul 2025 13:28 GMT
… including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and … protocols. Intergroup differentially expressed genes (DEGs) were identified by … to the pathogenesis of obesity.43
In summary, our … fatty liver disease in obese mice. Biomed Pharmacother. …