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Study Points to Promising Chemoimmunotherapy Strategy for Aggressive Stage III Non-Small Cell Lung Cancer
04 Jul 2025 12:40 GMT
… III Non-Small Cell Lung Cancer
Publication: JAMA Oncology
Corresponding … III non-small cell lung cancer that is considered difficult … with mutations in KRAS and STK11 or KRAS and KEAP1 did … stage III non-small cell lung cancer have limited treatment options. …
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Mutagenic Forces Shaping Lung Cancer Genomes
03 Jul 2025 02:59 GMT
… mutations in the KRAS gene were identified … landscape of lung cancerheterogeneity of lung cancerinternational lung cancer studyKRAS mutations … lung cancerregional differences in lung cancer mutationstobacco-free lung cancer casestreatment-naive lung cancer …
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CNS Surveillance and Management of Brain Metastases in Patients With KRAS G12C NSCLC
02 Jul 2025 13:43 GMT
… Metastases Management in KRAS G12C Patients Central … patients with KRAS G12C positive non–small cell lung cancer, presenting … CNS-penetrant targeted agents, KRAS G12C patients have limited … CNS response rates, while KRAS G12C inhibitors show approximately …
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Study maps HER2 mutations in lung cancer patients from Northeastern Brazil
28 Jun 2025 11:53 GMT
… HER2-mutated non-small cell lung cancer in Northeastern Brazil: Clinical … and gastric cancers. In lung cancer-particularly NSCLC-these mutations … genes such as TP53, KRAS, and STK11. The most … -mutated non-small cell lung cancer in Northeastern Brazil: Clinical …
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Blood-Based KRAS Testing Fails in Ovarian Cancer
24 Jun 2025 20:59 GMT
… with KRAS-mutated tumors makes accurate KRAS mutation … tumor tissue-confirmed KRAS mutations, blood-based … approach focusing specifically on KRAS mutations
“would potentially … lung cancer showing high discordance rates (primary tumor vs metastasis) in KRAS …
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Verastem Oncology Announces First Patient Dosed with VS-7375, an Oral KRAS G12D (ON/OFF) Inhibitor, in a U.S. Phase 1/2a Trial in KRAS G12D Advanced Solid Tumors
24 Jun 2025 20:13 GMT
… and non-small cell lung cancer. In parallel with the … , colorectal, and lung cancers.”
About KRAS G12D
KRAS G12D represents 26% … Administration (FDA) specifically targeting KRAS G12D mutations in cancer. … , FAK inhibition, and KRAS G12D inhibition. For more …
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New KRAS mutation discovery opens door to targeted colon cancer therapies
24 Jun 2025 18:36 GMT
… linked to cancer. KRAS mutations are especially prevalent … differences between three distinct KRAS mutations commonly found in … However, researchers saw that KRAS G12V synthesized acetyl-CoA … and lung cancer, two other types of cancer where KRAS mutations …
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Updates in Shared Decision-Making in Lung Cancer Following ASCO 2025
13 Jun 2025 22:46 GMT
… discussed what patients with lung cancer should know, especially … plenary sessions for lung cancer abstracts this year, … lung cancer (NSCLC) and small cell lung cancer. The progress [in small cell lung cancer … cell lung cancer.
We have approvals for 2 KRAS G12C …
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Bringing Light to More Personalized Medicine in Lung Cancer After ASCO 2025
12 Jun 2025 21:33 GMT
… all of oncology, including across lung cancer care. These updates are important … non-small cell lung cancer (NSCLC) whose disease has a KRAS G12c mutation …
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Revolution Medicines Announces FDA Breakthrough Therapy Designation for Daraxonrasib in Previously Treated Metastatic Pancreatic Cancer with KRAS G12 Mutations
23 Jun 2025 13:00 GMT
… PDAC in patients with KRAS G12 mutations. The Breakthrough … with ~85% carrying a KRAS G12 mutation. Revolution Medicines … (PDAC), non-small cell lung cancer (NSCLC) and colorectal cancer … -cancer genomic landscape of KRAS altered cancers and real …