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A Systematic Review of SNPs Screening for Platinum-Related Pharmacodynamics and Pharmacokinetics Genes in Non-Small Cell Lung Cancer for Precision Medicine
26 Jun 2025 22:33 GMT
… of drug resistance and the enhancement of treatment … 2015, advanced medications such as Crizotinib showed significant effectiveness … and meta-analysis. Pharmaceuticals. 2022;15(4). … Library of Medicine. National Center for Biotechnology Information. Non …
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Survival Outcomes in Lung Cancer Patients Newly Diagnosed Through Brain Metastasis Surgery: Impact of Druggable Mutations and Radiotherapy
25 Jun 2025 08:47 GMT
… of known druggable mutations.
Nowadays, the treatment for advanced … -metastases, previous clinical trials showed that cranial radiotherapy … revolution of small molecular medication, so-called target … al. Lorlatinib versus crizotinib in patients with advanced …
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Nuvalent Touts 'Positive' Data From Zidesamtinib Trial For Pretreated Patients With Advanced Form Of Lung Cancer
24 Jun 2025 16:53 GMT
… with one prior ROS1 TKI (crizotinib or entrectinib) ± chemotherapy, ORR … of the ALKAZAR Phase 3 trial, which will evaluate neladalkib … completed a pre-New Drug Application meeting with the … seeking an indication for the treatment of zidesamtinib in TKI- …
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Navigating the Treatment Landscape in Non–Clear Cell Renal Cell Carcinoma
23 Jun 2025 14:42 GMT
… historically excluded from RCC clinical trials, which mainly enrolled patients … German-led investigator-initiated randomized trial, patients with untreated metastatic … sunitinib with cabozantinib, crizotinib, and savolitinib for treatment of advanced papillary …
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Breaking Down Taletrectinib’s FDA Approval: Jorge J. Nieva, MD
21 Jun 2025 01:54 GMT
… over existing therapies like crizotinib (Xalkori; Pfizer) and … NSCLC, offering personalized treatment based on toxicity … of clinical medicine, Keck School of Medicine, and … www.fda.gov/drugs/;resources-information-approved-drugs/fda-approves …
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FDA clears Nuvation's first product Ibtrozi, for lung cancer
12 Jun 2025 12:58 GMT
… the FDA approved its ROS1 inhibitor Ibtrozi as a treatment for … "major milestone" in treatment, adding that Ibtrozi (taletrectinib) … s first-to-market Xalkori (crizotinib), Roche's Rozlytrek … drug has been approved on the back of two phase 3 trials …
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FDA Approves Taletrectinib in ROS1+ NSCLC
11 Jun 2025 17:43 GMT
… received prior treatment with crizotinib (Xalkori). The TRUST-II trial enrolled patients … TRUST-I and TRUST-II trials, including those who were … in December 2024.4
FDA approves taletrectinib for ROS1 … U.S. Food and Drug Administration accepts for priority …
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FDA Approves Taletrectinib for ROS1+ Advanced NSCLC
11 Jun 2025 23:27 GMT
… TRUST-II (NCT04919811) trials.1 Treatment-naive patients experienced an … in China during the trial. TRUST-II was … in the form of crizotinib or entrectinib (Rozlytrek). … ;www.fda.gov/drugs/;resources-information-approved-drugs/fda-approves- …
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FDA Backs Darovasertib Phase 3 Trial Design in Uveal Melanoma
14 Apr 2025 23:38 GMT
… second registrational trial," said Darrin Beaupre, MD, PhD, chief medical officer … crizotinib (Xalkori) in metastatic uveal melanoma in December 2022.2 The FDA … orphan drug designation for darovasertib, a PKC inhibitor, for the treatment of …
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Taletrectinib Shows Positive Efficacy and Toxicity in ROS1+ NSCLC
04 Jul 2025 01:31 GMT
… ) and TRUST-II (NCT04919811) trials, taletrectinib (Ibtrozi) demonstrated positive … ) in those who are treatment-naïve. He also spoke … associate professor of clinical medicine at the Keck School … than the drug that sort of started it all, crizotinib [Xalkori …