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New antiviral mechanism of action for an FDA-approved thiopurine known as 6-thioguanine
21 Sep 2022 13:50 GMT
… 6-thioguanine (6-TG).
Study: Thiopurines inhibit coronavirus Spike protein processing … present study previously demonstrated that thiopurines, 6-thioguanosine (6-TGo) … interfere with coronavirus (CoV) glycoproteins.
Thiopurine efficacy against severe SARS-CoV …
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Repeated Thiopurine metabolite monitoring and dose optimization tied to remission of IBD
07 Aug 2022 15:19 GMT
… found, metabolite monitoring of thiopurine therapy against inflammatory bowel disease … therapeutic and financial advantages of thiopurine metabolite monitoring, which is … C. (2022). Clinical utility of thiopurine metabolite monitoring in inflammatory bowel …
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Patients with CC genotype at higher risk for azathioprine discontinuation attributed to hematopoietic toxicity and lower thiopurine doses, even after adjusting for race
21 Jun 2022 01:07 GMT
… to hematopoietic toxicity and lower thiopurine doses, even after adjusting for … in Annals of Internal Medicine.
Thiopurine azathioprine, an immunosuppressant used to … associated with a difference in thiopurine discontinuation and tolerated dose across …
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Study reports thiopurines inhibit the replication of the betacoronaviruses HCoV-OC43 and SARS-CoV-2
17 Mar 2022 17:30 GMT
… server, researchers demonstrated that the thiopurines block coronaviruses (CoVs) spike … into progeny virions.
Study: Thiopurines inhibit coronavirus Spike protein processing … the emerging viral infections.
Thiopurines were used as immunomodulators and …
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Thiopurines could help stop viral replication in human coronaviruses
06 Oct 2020 04:43 GMT
… -CoV-2).
Their study titled, “Thiopurines activate an antiviral unfolded protein … team identified two FDA-approved thiopurine analogs called “6- thioguanine (6 … as established information.
Journal reference:
Thiopurines activate an antiviral unfolded protein …
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Simple DNA test can predict risk of bad side effects to thiopurine drugs
02 Jul 2018 10:46 GMT
… to have bad reactions to thiopurine medications.
Thiopurine drugs are prescribed to … .
Previous research had linked severe thiopurine side effects with different expressions … the patients' reactions to thiopurines. They also conducted several other …
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Lymphoma risk up with thiopurine, anti-TNF Tx in IBD
10 Nov 2017 04:30 GMT
… increased with use of thiopurine monotherapy, anti-tumor necrosis … in patients exposed to thiopurine monotherapy, 32 in patients … for those exposed to thiopurine monotherapy, anti-TNF monotherapy … to combination therapy versus thiopurine monotherapy or anti-TNF …
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Aminosalicylates or Thiopurines and CRC Risk in IBD
23 Feb 2017 06:11 GMT