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Hyundai Bioscience Announces Clinical Development Plan for Niclosamide-based Metabolic Anticancer Drug Targeting P53 Mutation Cancer
25 Apr 2024 12:01 GMT
… by mutations in the p53 gene
Planning clinical trials targeting … no available treatment due to p53 gene mutations
SEOUL, South Korea … caused by p53 gene mutations. Mutations in the p53 gene occur in … esophageal cancer, etc.
The p53 gene acts as the " …
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A Novel Four-Gene Signature Based on Nonsense-Mediated RNA Decay for Predicting Prognosis in Hepatocellular Carcinoma: Bioinformatics Analysis and Functional Validation
23 Apr 2024 07:54 GMT
… selectively downregulates tumor-suppressor gene (TSG) expression and … UPF1 dephosphorylation by recruiting protein phosphatase 2A, and … thereby restoring regular gene expression and protein function.39,40 … BRCA1, CHK2, and p53 proteins? Hum Mutat. 2008; …
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Construction of an Immunogenic Cell Death-Related Gene Signature and Genetic Subtypes for Predicting Prognosis, Immune Microenvironments, and Drug Sensitivity in Hepatocellular Carcinoma
22 Apr 2024 07:48 GMT
… Subtypes in HCC Patients
Protein-protein interaction (PPI) analysis … serum; GO, Gene ontology; GSEA, gene set enrichment analysis; … OS, overall survival; PPI, Protein-protein interaction; ROC, receiver operating … and radiosensitivity of P53 mutant HCC cells …
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Identification and Verification of Ferroptosis-Related Genes in Keratoconus Using Bioinformatics Analysis
20 Apr 2024 12:31 GMT
… of the optimal gene biomarkers.
Single-Gene Gene Set Enrichment … separately for upregulated genes and downregulated genes (Figure S1). … selected as marker genes. These marker genes included H19, … D. The tumor suppressor protein p53 and the ferroptosis network. …
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Elicio Therapeutics to Present New Preliminary Data from the Ongoing AMPLIFY-7P Phase 1/2 Study of ELI-002 7P in Patients with mKRAS-driven Solid Tumors at the 2024 ASCO Annual Meeting
25 Apr 2024 12:30 GMT
… by mutations in the mKRAS-gene—a prevalent driver of many … (targeting BRAF-driven cancers and p53 hotspot mutations, respectively). For more …
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Clinical Significance of Uncommon, Non-Clinical, and Novel Autoantibodies
25 Apr 2024 03:19 GMT
… in individuals with specific genetic predisposition. Specific patterns … recognizing certain intracellular proteins can target cell … directed against extracellular proteins are often directly … ;MORC3 matrix protein complex, which regulates p53-induced cell …
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ASCO 2024 | Ascentage Pharma to Present Four Studies, Including an Oral Report Featuring the Latest Data of Olverembatinib in SDH-Deficient GIST
25 Apr 2024 03:36 GMT
… cancer (NSCLC) resistant to second-generation ALK inhibitors.
Abstract#: 3124
Format … on developing therapeutics that inhibit protein-protein interactions to restore apoptosis, or … at IAP and MDM2-p53 pathways, and next-generation tyrosine kinase inhibitors …
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Unraveling the Molecular Regulation of Ferroptosis in Respiratory Diseases
24 Apr 2024 12:42 GMT
… cystine-glutamate antitransfer proteins. These proteins facilitate cysteine … a tumor suppressor gene, the P53 gene also has a … genes associated with iron metabolism, including iron transporter proteins … expression of associated genes, P53 can influence the …
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Self-Amplified pH/ROS Dual-Responsive Co-Delivery Nano-System with Chemo-Photodynamic Combination Therapy in Hepatic Carcinoma Treatment
24 Apr 2024 07:54 GMT
… including apoptosis induction through p53 activation, modulation of … intensity, reflecting ROS generation, was significantly higher … cell proliferation, ROS generation, and apoptosis induction. … Reactive oxygen species generating systems meeting challenges …
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Research Progress of Baihe Gujin Decoction in the Treatment of Lung Cancer
23 Apr 2024 17:30 GMT
… (HIF-1α), P53, and survivin mRNA and protein. Zhou26 et al … the levels of C-reaction protein (CRP), procalcitonin (PCT), TNF … apoptosis. Kyoto Encyclopedia of Genes and Genomes pathway analysis … , promote essence and blood generation, and purge the deficient …