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Type I interferon regulates interleukin-1beta and IL-18 production and secretion in human macrophages
25 Mar 2024 22:59 GMT
Introduction
The innate immune system plays a fundamental role in recognising and responding to invading pathogens and damage signals. One important component of this response is the inflammasome, a multiprotein complex that upon activation and assembly …
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Highly Effective Therapies Found Superior to Moderately Effective Therapies as First-Line Treatment in Pediatric MS
06 Mar 2024 23:17 GMT
… only disease-modifying therapies FDA-approved for use in children … , glatiramer acetate, dimethyl fumarate, interferon beta, and teriflunomide. Highly effective therapies … researchers found that both treatment strategies significantly reduced relapses during …
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Ozanimod's Consistent Efficacy in Long-Term Treatment for Multiple Sclerosis: Jeffery Cohen, MD
01 Mar 2024 19:32 GMT
… age.”
In phase 3 randomized trials (SUNBEAM, NCT02294058; RADIANCE, NCT02047734 … T2 lesions compared with interferon (IFN) beta-1a in patients … trial baseline after 7 to 8 years on ozanimod treatment, … and the impact of medications like ozanimod. Despite the …
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Nona Biosciences Enters into Collaboration Agreement with Boostimmune in Antibody-Drug Conjugate Development
27 Feb 2024 04:27 GMT
… Boostimmune, a biotech company dedicated to … anticipate delivering transformative treatments, ultimately improving outcomes … transformative next-generation drugs. For more … originally identified interferon beta, interleukin-2, and interferon regulatory factors …
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Highly effective treatments for pediatric onset MS linked to best outcomes at 2 years
22 Feb 2024 18:02 GMT
… -onset multiple sclerosis, treatment with commonly known highly … treatments such as azathioprine, cyclophosphamide, dimethyl fumarate, glatiramer acetate, interferon beta, … ), tertiary education attainment and treatment safety/tolerability.
Benallegue …
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Actives from the Micro-Immunotherapy Medicine 2LMIREG® Reduce the Expression of Cytokines and Immune-Related Markers Including Interleukin-2 and HLA-II While Modulating Oxidative Stress and Mitochondrial Function
21 Feb 2024 08:22 GMT
… -steroidal anti-inflammatory drugs on mitochondrial health, … batch number #P170201, PAN-Biotech GmbH, Aidenbach, Germany). … 48 hours. Concomitant treatments with activating stimuli were … . The unitary micro-immunotherapy medicine interferon-γ (4 CH) displays …
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Multiple Sclerosis Market Size in the 7MM was ~USD 25 Billion in 2022, estimated DelveInsight
27 Mar 2024 11:32 GMT
… Fludarabine, Cyclophosphamide, Interferon beta-1a (Rebif), … Biotechnology)
Multiple Sclerosis Treatment Landscape
Multiple Sclerosis treatment … drug is being studied in three Phase III trials for the treatment … pharmaceutical-grade water. The drug …
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Evolution of Peritoneal Dialysis-Associated Peritonitis: Pathogen, Antibiotic Resistance, and the Impact of Lymphocyte Count on Treatment Outcomes
19 Feb 2024 07:39 GMT
… ischemia of intraabdominal organs. Medical cure was defined as … granulocyte colony-stimulating factor, interferon-gamma-inducible protein 10, … increase in drug resistance with our empirical treatment. Vancomycin, … Price LS. The new beta-lactamases. New Engl J …
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Disproportionate Neurodegeneration in Black Patients With MS: The Need for Stratified Treatments
13 Feb 2024 21:45 GMT
… effective management of any medical condition. Commonly, therapeutic … field. The current FDA-approved disease-modifying therapies … groups within large clinical trials, as published data … D. Response to interferon beta-1a treatment in African American multiple …
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Network Pharmacology, Molecular Docking, and Experimental Verification to Reveal the Mitophagy-Associated Mechanism of Tangshen Formula in the Treatment of Diabetic Nephropathy
13 Feb 2024 05:47 GMT
… and uncover associations between drugs, genes, and … on their physiology and pharmaceutical relevance significance. The … Clinical trials of traditional Chinese medicine in the treatment of … Diabetic Nephropathy by targeting interferon regulatory factor 4. …