-
Combinatorial CRISPR screen reveals FYN and KDM4 as targets for synergistic drug combination for treating triple negative breast cancer
29 Feb 2024 19:49 GMT
… microarray data of primary breast cancers of GSE25066 cohort, and … upregulation in triple-negative breast cancer (TNBC) compared to … NVP-ADW742 treatment, gefitinib treatment increased KDM4 demethylase … various cancers, including breast cancer, and promotes key …
-
Molecular Biology Mechanisms and Emerging Therapeutics of Triple-Negative Breast Cancer
20 Sep 2023 16:40 GMT
… approach to characterizing breast tumors.26 Based on … portraits of human breast tumours. Nature. 2012;490 … medullary breast cancer is a subgroup of basal breast cancers. … gefitinib in taxane- and anthracycline-pretreated metastatic breast cancer. Breast Cancer …
-
Research Progress on Molecular Subtyping and Modern Treatment of Triple-Negative Breast Cancer
24 Aug 2023 08:11 GMT
… stage breast cancer patients, patients were given either gefitinib … of triple negative breast cancers expressing CTLA-4. … -negative breast tumor growth by targeting GD2 + breast cancer stem … in triple-negative breast cancer. Breast Cancer Res Treat. 2022 …
-
Informatics on Drug Repurposing for Breast Cancer
28 Jun 2023 02:25 GMT
… similar to lapatinib and gefitinib, two well-known … of triple negative breast cancer: understanding the diversity … based drug repositioning for breast cancer molecular subtypes. Front Pharmacol … repurposing approach for breast cancer via integrated functional …
-
GW4869 Can Inhibit Epithelial-Mesenchymal Transition and Extracellular HSP90α in Gefitinib-Sensitive NSCLC Cells
07 Nov 2023 13:45 GMT
… into three groups: control, gefitinib, gefitinib+GW4869 (Figure 4A). By … groups treated with gefitinib and gefitinib+GW4869.Tumor size … in tumor research, including breast cancer, prostate cancer, melanoma, … T Cell Killing of Breast Cancer Cells and Promote …
-
Preparation and Evaluation of Chitosan Coated PLGA Nanoparticles Encapsulating Ivosidenib with Enhanced Cytotoxicity Against Human Liver Cancer Cells
09 Apr 2024 06:51 GMT
… and hydrogels in breast cancer: immunotherapy, phototherapy … sunitinib malate in breast cancer through lipid polymer … gefitinib-loaded solid lipid nanoparticles for the treatment of breast cancer … and anticancer activity in breast cancer (MCF-7) cells. …
-
Patritumab Deruxtecan Continues to Show Encouraging Clinical Activity in Distinct Patient Populations with Metastatic Lung and Breast Cancer in Updated Results of Two Early Trials
20 Mar 2023 03:02 GMT
… breast tumors.3,4,5
"Most patients with lung or breast cancer … progression on erlotinib, gefitinib or afatinib. The … breast cancer, including HR positive and triple negative breast cancer. … mutated NSCLC.
About Breast Cancer
Breast cancer is the most …
-
Patritumab Deruxtecan Continues to Show Encouraging Clinical Activity in Distinct Patient Populations with Metastatic Lung and Breast Cancer in Updated Results of Two Early Trials
20 Mar 2023 01:19 GMT
… breast tumors.3,4,5
“Most patients with lung or breast cancer … progression on erlotinib, gefitinib or afatinib. The … breast cancer, including HR positive and triple negative breast cancer. … mutated NSCLC.
About Breast Cancer
Breast cancer is the most common …
-
Dual Target of EGFR and mTOR Suppresses Triple-Negative Breast Cancer Cell Growth by Regulating the Phosphorylation of mTOR Downstream Proteins
17 Jan 2023 14:43 GMT
… Breast cancer is highly heterogeneous, with different types of breast cancers … triple-negative breast cancer: a review. Breast Cancer Res Treat … of gefitinib in patients with advanced breast cancer. J … in triple-negative breast cancer. Breast Cancer Res Treat. …
-
A Primary Lung and Breast Cancer Patient with Germline EGFR R776H Mutation: A Case Report and Literature Review
17 Jan 2023 14:43 GMT
… I (pT1cN0M0) primary breast cancer, which was surgically removed … patient was subsequently given Gefitinib (250 mg once … treatment.
Abbreviations: BC, breast cancer; LUAD, lung adenocarcinoma. … breast cancer. (B–E) IHC examinations (200×) of the breast tumor …