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AlzeCure Pharma Broadcasts Live Expert Event on Alzheimer's Around Highly Current Gamma-Secretase Modulators
12 Feb 2024 12:29 GMT
… s disease - Small molecule gamma-secretase modulators (GSMs) as promising disease … by gamma-secretase, a major limitation of first-generation gamma-secretase inhibitors … 39;s around highly current gamma-secretase modulators
SOURCE: AlzeCure Pharma
View …
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Development and Characterization of a Novel Carbon-11 Labeled Positron Emission Tomography Radiotracer for Neuroimaging of Sirtuin 1 with Benzoxazine-Based Compounds
15 Mar 2024 09:12 GMT
… urgent demand for next-generation modulators with enhanced specificity for sirtuin … the discovery of sirtuin 1 modulators. Tremendous efforts, including contributions from … of Alzheimer’s disease-related gamma-secretase in mice and nonhuman primates …
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Molecular imaging probe reveals Alzheimer's-related γ-secretase in rodents, macaques
18 Sep 2020 05:31 GMT
… to develop molecules that target gamma-secretase for the treatment and … first developed the concept of gamma-secretase modulators (GSMs), which preferentially reduce … molecule for better understanding how gamma-secretase contributes to AD pathogenesis.
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Pharvaris’ $300 million public offering; Genentech’s breast cancer trial success; new neuromuscular disease target discovered
15 Dec 2023 17:58 GMT
… an oral, selective, small molecule gamma secretase inhibitor that is being evaluated … ’s emraclidine, a positive allosteric modulator (PAM) of the muscarinic M4 …
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Seven companies shaping the future of precision medicine
14 Dec 2023 17:03 GMT
… respond to drugs like CFTR modulators, which are typically administered to … specializes in targeted oncology. Its gamma secretase inhibitor called nirogacestat has received … tissue. Nirogacestat works by inhibiting gamma secretase, an enzyme that aids in …
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AlzeCure Publishes New Article on the GSM Mechanism Behind Alzstatin Against Alzheimer's Disease
17 Oct 2023 11:03 GMT
… available online.
The article, titled Gamma-secretase modulators: a promising route for the … is important for the field.
Gamma-secretase modulators reduce the production of toxic … phase I data with its gamma-secretase modulator on CTAD congress further …
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Will there ever be a cure for Alzheimer’s disease?
21 Sep 2023 08:00 GMT
… antibodies to neutralise toxic amyloid.”
Gamma secretase modulators (GSMs) are another novel idea …
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AlzeCure Presents New Data on its Preventive Treatment Alzstatin at the Alzheimer's Conference AD/PD 2023
28 Mar 2023 11:25 GMT
… that AlzeCure is pursuing a gamma-secretase modulator (GSM) project. There is so … AC-0027875 (ACD680), a novel gamma-secretase modulator for the prevention and treatment … in our models, and a gamma-secretase modulator such as this is particularly …