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News24 | Widely used HIV drug in SA flagged for reports of resistance - but experts say don't panic
15 Apr 2024 11:06 GMT
… published in the Lancet medical journal found that people … with the WHO report stating that the levels of … end is a robust drug like darunavir. Dolutegravir falls on the … HIV treatment programmes compared to clinical trial data because the trials follow …
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Outcome of Darunavir–Cobicistat-Based Regimens in HIV-Infected People Who Have Experienced Virological Failure
10 Apr 2024 07:10 GMT
… fewer side effects and drug–drug interactions.12–14 The … of reduction in pill burden and medication errors.15 Both … data from two randomised trials. Lancet. 2007;369( … trial of darunavir/cobicistat/emtricitabine/tenofovir alafenamide in treatment …
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FDA Approved Drug Products Approval List March 2024
30 Mar 2024 10:39 GMT
… 214369 ORIG-1 RIFAXIMIN NORWICH PHARMACEUTICALS INC Tentative Approval 03 … 761044 SUPPL-13 USTEKINUMAB JANSSEN BIOTECH Approval 03/ … SUPPL-15 PRALSETINIB BLUEPRINT MEDICINES Labeling Approval 03… #202136 ORIG-1 DARUNAVIR MYLAN PHARMS INC …
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The cornerstone of HIV treatment may be losing some of its power: will dolutegravir resistance become a problem?
12 Mar 2024 17:37 GMT
… treatment fails or if a person cannot tolerate first-line drugs … levels observed in clinical trials”. The next day, … the Salvador Zubiran National Medical and Nutrition Science … people on dolutegravir and darunavir respectively maintained viral undetectability …
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Varying dolutegravir distribution across the body may affect the drug’s ability to suppress the HIV reservoir
05 Mar 2024 20:54 GMT
… darunavir in their regimen which allowed for the sampling of these drugs … and intestines.
Takeaway
In HIV treatment, drug concentration often correlates with viral … -optimal concentrations may lead to treatment failure. Due to physiological differences …
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Serum Lipid Profiles, Blood Glucose, and High-Sensitivity C-Reactive Protein Levels Among People Living with HIV Taking Dolutegravir and Ritonavir-Boosted Atazanavir-Based Antiretroviral Therapy at Jimma University Medical Center, Southwest Ethiopia, 2021
12 Feb 2024 10:36 GMT
… therapy at Jimma University Medical Center, Southwest Ethiopia. … associated dyslipidaemia: pathogenesis and treatment. Lancet Infect Dis. … 47; Ritonavir. HIV Clin Trials. 2015;13(5):245 … with atazanavir-, raltegravir-, darunavir-based initial antiviral therapy: …
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People with HIV still running out of treatment options – not always because of resistance
16 Jan 2024 07:13 GMT
… restrict their treatment options. Resistance to three drug classes can … and Israel.
Using treatment records only, as drug resistance data were … darunavir) in a three-drug regimen, or
taking a two-drug … on a two-drug regimen (containing darunavir in 62% of …
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Opinion/decision on a Paediatric investigation plan (PIP): Symtuza, darunavir,cobicistat,emtricitabine,tenofovir alafenamide, decision type: PM: decision on the application for modification of an agreed PIP, therapeutic area: Infectious diseases, PIP…
11 Jan 2024 14:17 GMT
P/0198/2021 : EMA decision of 10 May 2021 on the acceptance of a modification of an agreed paediatric investigation plan for darunavir / cobicistat / emtricitabine / tenofovir alafenamide (Symtuza), (EMEA-001825-PIP01-15-M03)
…
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Opinion/decision on a Paediatric investigation plan (PIP): Rezolsta, darunavir,cobicistat, decision type: PM: decision on the application for modification of an agreed PIP, therapeutic area: Infectious diseases, PIP number: P/0039/2023
11 Jan 2024 09:29 GMT
P/0254/2021: EMA decision of 9 July 2021 on the acceptance of a modification of an agreed paediatric investigation plan for darunavir / cobicistat (Rezolsta), (EMEA-001280-PIP01-12-M04)
First published: 25/07/2022Reference Number: EMA…
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Zydus receives final approval from the USFDA for Darunavir Tablets 600 mg and 800 mg, and tentative approval for 75 mg and 150 mg tablets
16 Dec 2023 18:32 GMT
… States Food and Drug Administration (USFDA) for Darunavir Tablets 600 mg … 800 mg).
Darunavir is a protease inhibitor antiviral medicine that prevents … is indicated for the treatment of HIV-1 infection in … is also indicated for the treatment of HIV-1 infection …