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Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)
30 Apr 2024 14:41 GMT
… events and therapeutic resistance in 5-FU chemotherapy at opposite ends of the … for 5-FU toxicity risk and potentially tumor resistance to 5-FU–based cancer therapy … in colorectal cancer and in other solid cancers frequently treated with 5-FU.
The …
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Denovo Biopharma’s glioma gene therapy trial receives CIRM grant
01 May 2024 10:58 GMT
… ), a deadly form of brain cancer.
The trial will assess the … 5-FC into the potent chemotherapeutic agent 5-fluorouracil (5-FU) at the tumour sites …
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Merck's phase 3 KEYNOTE─811 trial of Keytruda in combo with trastuzumab and fluoropyrimidine─ and platinum─containing chemotherapy meets dual primary endpoint of OS in patients with HER2─positive advanced gastric or GEJ adenocarcinoma
03 May 2024 07:24 GMT
… chemotherapy (investigator’s choice of 5-fluorouracil plus cisplatin or capecitabine plus …
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Pembrolizumab Combo Yields Significant OS in HER2+ Gastric/GEJ Cancer
02 May 2024 19:01 GMT
… and investigator’s choice of 5-fluorouracil plus cisplatin or capecitabine plus …
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NuCana Regains Compliance with Nasdaq Minimum Bid Price Requirement
01 May 2024 20:01 GMT
… derived from the nucleoside analog 5-fluorouracil, a widely used chemotherapy agent …
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Metabolic heterogeneity of colorectal cancer as a prognostic factor: insights gained from fluorescence lifetime imaging
01 May 2024 19:01 GMT
… cells cultures after chemotherapy with 5-fluorouracil. Here, we used the dispersion …
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Merck Announces Phase 3 KEYNOTE-811 Trial Met Dual Primary Endpoint of Overall Survival (OS) as First-Line Treatment in Patients With HER2-Positive Advanced Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma
01 May 2024 11:26 GMT
… chemotherapy (investigator’s choice of 5-fluorouracil plus cisplatin or capecitabine plus …
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Anova to Manage Study of DB107 Following Newly Awarded $11.8M CIRM Grant
01 May 2024 09:37 GMT
… prodrug of 5-FU (5-FC), to selectively infect and kill cancer cells … a robust and durable anti-cancer immune response against a tumor … high-grade GBM and colorectal cancer, most recently in a randomized …
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FOLFIRI Plus ICIs Display Anti-Tumor Activity in Gastric/GEJ Cancer
30 Apr 2024 19:28 GMT
… 400 mg/m2, a 5-fluorouracil bolus at 400 mg… ;m2, continuous 5-fluorouracil at 2400 mg/m2 …
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A Review and Case Study of Genital and Extragenital Human Papillomavirus Type 6 and 11 Infections in Men Who Have Sex with Men Accompanied by Human Immunodeficiency Virus Infection
30 Apr 2024 13:14 GMT
… , surgical excision, and interferon or 5-fluorouracil/epinephrine gel implants.3 …